Fan Fan

2024

Impact of knockout of dual-specificity protein phosphatase 5 on structural and mechanical properties of rat middle cerebral arteries: implications for vascular aging

Tang, C., Zhang, H., Border, J. J., Liu, Y., Fang, X., Jefferson, J. R., Gregory, A., Johnson, C., Lee, T. J., Bai, S., Sharma, A., Shin, S. M., Yu, H., Roman, R. J. & Fan, F., Jan 10 2024, In: GeroScience.

Research output: Contribution to journal › Article › peer-review

2023

Knockout of Matrix Metalloproteinase 2 Opposes Hypertension- and Diabetes-induced Nephropathy

Hirata, T., Fan, F., Fan, L., Amin, G., White, T., Geurts, A. M., Kojima, N., Takahashi, T., Miyata, N., Williams, J. & Roman, R. J., Dec 30 2023, In: Journal of Cardiovascular Pharmacology. 82, 6, p. 445-457 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Amyloid beta accumulation in TgF344-AD rats is associated with reduced cerebral capillary endothelial Kir2.1 expression and neurovascular uncoupling

Fang, X., Border, J. J., Rivers, P. L., Zhang, H., Williams, J. M., Fan, F. & Roman, R. J., Oct 2023, In: GeroScience. 45, 5, p. 2909-2926 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Longitudinal characterization of cerebral hemodynamics in the TgF344-AD rat model of Alzheimer’s disease

Fang, X., Tang, C., Zhang, H., Border, J. J., Liu, Y., Shin, S. M., Yu, H., Roman, R. J. & Fan, F., Jun 2023, In: GeroScience. 45, 3, p. 1471-1490 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Peripheral sensory neurons and non-neuronal cells express functional Piezo1 channels

Shin, S. M., Itson-Zoske, B., Fan, F., Gani, U., Rahman, M., Hogan, Q. H. & Yu, H., Jan 1 2023, In: Molecular Pain. 19

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2022

Targeting intrinsically disordered regions facilitates discovery of calcium channels 3.2 inhibitory peptides for adeno-associated virus-mediated peripheral analgesia

Shin, S. M., Lauzadis, J., Itson-Zoske, B., Cai, Y., Fan, F., Natarajan, G. K., Kwok, W. M., Puopolo, M., Hogan, Q. H. & Yu, H., Dec 1 2022, In: Pain. 163, 12, p. 2466-2484 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Renoprotective effects of empagliflozin in type 1 and type 2 models of diabetic nephropathy superimposed with hypertension

Williams, J. M., Murphy, S. R., Wu, W., Border, J. J., Fan, F. & Roman, R. J., Dec 2022, In: GeroScience. 44, 6, p. 2845-2861 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Selective block of sensory neuronal T-type/Cav3.2 activity mitigates neuropathic pain behavior in a rat model of osteoarthritis pain

Itson-Zoske, B., Shin, S. M., Xu, H., Qiu, C., Fan, F., Hogan, Q. H. & Yu, H., Dec 2022, In: Arthritis Research and Therapy. 24, 1, 168.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

TMEM173 rs7447927 genetic polymorphism and susceptibility to severe enterovirus 71 infection in Chinese children

Song, J., Liu, Y., Guo, Y., Qu, Z., Liu, P., Li, F., Yang, C., Fan, F. & Chen, Z., Dec 2022, In: Immunity, inflammation and disease. 10, 12, e742.

Research output: Contribution to journal › Article › peer-review

Open Access

Turn Up the Hydroxyeicosatetraenoic on Septic Shock

Thomas, K., Strong, L., Fan, F. & Roman, R. J., Aug 1 2022, In: Journal of Cardiovascular Pharmacology. 80, 2, p. 206-209 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Association of the IRAK4 rs4251545 genetic polymorphism with severity of enterovirus-71 infection in Chinese children

Song, J., Liu, Y., Guo, Y., Liu, P., Li, F., Yang, C., Pan, X., Yi, L., Fan, F., Zhao, H. & Chen, Z., May 2022, In: Immunity, inflammation and disease. 10, 5, e614.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

CD44 mediates shear stress mechanotransduction in an in vitro blood-brain barrier model through small GTPases RhoA and Rac1

DeOre, B. J., Partyka, P. P., Fan, F. & Galie, P. A., May 2022, In: FASEB Journal. 36, 5, e22278.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Luseogliflozin, a sodium-glucose cotransporter-2 inhibitor, reverses cerebrovascular dysfunction and cognitive impairments in 18-mo-old diabetic animals

Wang, S., Jiao, F., Border, J. J., Fang, X., Crumpler, R. F., Liu, Y., Zhang, H., Jefferson, J., Guo, Y., Elliott, P. S., Thomas, K. N., Strong, L. B., Urvina, A. H., Zheng, B., Rijal, A., Smith, S. V., Yu, H., Roman, R. J. & Fan, F., Feb 2022, In: American Journal of Physiology - Heart and Circulatory Physiology. 322, 2, p. H246-H259

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Traumatic brain injury induced by exposure to blast overpressure via ear canal

Ou, Y., Clifton, B. A., Li, J., Sandlin, D., Li, N., Wu, L., Zhang, C., Chen, T., Huang, J., Yu, Y., Allison, J., Fan, F., Roman, R. J., Shaffery, J., Zhou, W., Pang, Y. & Zhu, H., Jan 2022, In: Neural Regeneration Research. 17, 1, p. 115-121 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2021

Piezo2 mechanosensitive ion channel is located to sensory neurons and nonneuronal cells in rat peripheral sensory pathway: implications in pain

Shin, S. M., Moehring, F., Itson-Zoske, B., Fan, F., Stucky, C. L., Hogan, Q. H. & Yu, H., Nov 1 2021, In: Pain. 162, 11, p. 2750-2768 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility

Liu, Y., Zhang, H., Wu, C. Y., Yu, T., Fang, X., Ryu, J. J., Zheng, B., Chen, Z., Roman, R. J. & Fan, F., Jun 2021, In: Prostaglandins and Other Lipid Mediators. 154, 106548.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Aging diabetes, deconstructing the cerebrovascular wall

Fan, F., Booz, G. W. & Roman, R. J., Apr 15 2021, In: Aging. 13, 7, p. 9158-9159 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Knockout of g-adducin promotes N^G-nitro-L-arginine-methyl-ester–induced hypertensive renal injury

Fan, L., Gao, W., Liu, Y., Jefferson, J. R., Fan, F. & Roman, R. J., Apr 1 2021, In: Journal of Pharmacology and Experimental Therapeutics. 377, 1, p. 189-198 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Reduced pericyte and tight junction coverage in old diabetic rats are associated with hyperglycemia-induced cerebrovascular pericyte dysfunction

Liu, Y., Zhang, H., Wang, S., Guo, Y., Fang, X., Zheng, B., Gao, W., Yu, H., Chen, Z., Roman, R. J. & Fan, F., Feb 2021, In: American Journal of Physiology - Heart and Circulatory Physiology. 320, 2, p. H549-H562

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

Role of γ-adducin in actin cytoskeleton rearrangements in podocyte pathophysiology

Gao, W., Liu, Y., Fan, L., Zheng, B., Jefferson, J. R., Wang, S., Zhang, H., Fang, X., Nguyen, B. V., Zhu, T., Roman, R. J. & Fan, F., 2021, In: American Journal of Physiology - Renal Physiology. 320, 1, p. F97-F113

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2020

Angiotensin II type 1 receptor autoantibody blockade improves cerebral blood flow autoregulation and hypertension in a preclinical model of preeclampsia

Duncan, J. W., Azubuike, D., Booz, G. W., Fisher, B., Williams, J. M., Fan, F., Ibrahim, T., LaMarca, B. & Cunningham, M. W., Nov 2020, In: Hypertension in Pregnancy. 39, 4, p. 451-460 10 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats

Wang, S., Lv, W., Zhang, H., Liu, Y., Li, L., Jefferson, J. R., Guo, Y., Li, M., Gao, W., Fang, X., Paul, I. A., Rajkowska, G., Shaffery, J. P., Mosley, T. H., Hu, X., Liu, R., Wang, Y., Yu, H., Roman, R. J. & Fan, F., Oct 1 2020, In: GeroScience. 42, 5, p. 1387-1410 24 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

Impaired renal hemodynamics and glomerular hyperfiltration contribute to hypertension-induced renal injury

Fan, L., Gao, W., Nguyen, B. V., Jefferson, J. R., Liu, Y., Fan, F. & Roman, R. J., Oct 2020, In: American Journal of Physiology - Renal Physiology. 319, 4, p. F624-F635

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Vascular-Cognitive Impairment following High-Thoracic Spinal Cord Injury Is Associated with Structural and Functional Maladaptations in Cerebrovasculature

Sachdeva, R., Jia, M., Wang, S., Yung, A., Zheng, M. M. Z., Lee, A. H. X., Monga, A., Leong, S., Kozlowski, P., Fan, F., Roman, R. J., Phillips, A. A. & Krassioukov, A. V., Sep 15 2020, In: Journal of Neurotrauma. 37, 18, p. 1963-1970 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

20-HETE Enzymes and Receptors in the Neurovascular Unit: Implications in Cerebrovascular Disease

Gonzalez-Fernandez, E., Staursky, D., Lucas, K., Nguyen, B. V., Li, M., Liu, Y., Washington, C., Coolen, L. M., Fan, F. & Roman, R. J., Sep 4 2020, In: Frontiers in Neurology. 11, 983.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Association of CD14 rs2569190 G/A genetic polymorphism with the severity of enterovirus 71 infection in Chinese children

Guo, Y., Liu, Y., Song, J., Liu, P., Wu, S., Tan, Y., Fan, F. & Chen, Z., Sep 2020, In: Virology. 548, p. 25-30 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Development and Validation of a Prognostic Nomogram to Predict Cancer-Specific Survival in Adult Patients With Pineoblastoma

Jing, Y., Deng, W., Zhang, H., Jiang, Y., Dong, Z., Fan, F. & Sun, P., Jul 24 2020, In: Frontiers in Oncology. 10, 1021.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Sex differences in the structure and function of rat middle cerebral arteries

Wang, S., Zhang, H., Liu, Y., Li, L., Guo, Y., Jiao, F., Fang, X., Jefferson, J. R., Li, M., Gao, W., Gonzalez-Fernandez, E., Maranon, R. O., Pabbidi, M. R., Liu, R., Alexander, B. T., Roman, R. J. & Fan, F., May 2020, In: American Journal of Physiology - Heart and Circulatory Physiology. 318, 5, p. H1219-H1232

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Accelerated cerebral vascular injury in diabetes is associated with vascular smooth muscle cell dysfunction

Guo, Y., Wang, S., Liu, Y., Fan, L., Booz, G. W., Roman, R. J., Chen, Z. & Fan, F., Apr 1 2020, In: GeroScience. 42, 2, p. 547-561 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

A mutation in γ-adducin impairs autoregulation of renal blood flow and promotes the development of kidney disease

Fan, F., Geurts, A. M., Pabbidi, M. R., Ge, Y., Zhang, C., Wang, S., Liu, Y., Gao, W., Guo, Y., Li, L., He, X., Lv, W., Muroya, Y., Hirata, T., Prokop, J., Booz, G. W., Jacob, H. J. & Roman, R. J., Apr 2020, In: Journal of the American Society of Nephrology. 31, 4, p. 687-700 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Influence of dual-specificity protein phosphatase 5 on mechanical properties of rat cerebral and renal arterioles

Zhang, H., Zhang, C., Liu, Y., Gao, W., Wang, S., Fang, X., Guo, Y., Li, M., Liu, R., Roman, R. J., Sun, P. & Fan, F., Jan 1 2020, In: Physiological reports. 8, 2, e14345.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2019

The angiotensin II type i receptor contributes to impaired cerebral blood flow autoregulation caused by placental ischemia in pregnant rats

Warrington, J. P., Fan, F., Duncan, J., Cunningham, M. W., Lamarca, B. B., Dechend, R., Wallukat, G., Roman, R. J., Drummond, H. A., Granger, J. P. & Ryan, M. J., Dec 11 2019, In: Biology of Sex Differences. 10, 1, 58.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Visualization of the intrarenal distribution of capillary blood flow

Fan, L., Wang, S., He, X., Gonzalez-Fernandez, E., Lechene, C., Fan, F. & Roman, R. J., Apr 2019, In: Physiological reports. 7, 8, e14065.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Knockout of dual-specificity protein phosphatase 5 protects against hypertension-induced renal injury

Zhang, C., He, X., Murphy, S. R., Zhang, H., Wang, S., Ge, Y., Gao, W., Williams, J. M., Geurts, A. M., Roman, R. J. & Fan, F., 2019, In: Journal of Pharmacology and Experimental Therapeutics. 370, 2, p. 206-217 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

2018

Targeting vascular inflammation in ischemic stroke: Recent developments on novel immunomodulatory approaches

Shekhar, S., Cunningham, M. W., Pabbidi, M. R., Wang, S., Booz, G. W. & Fan, F., Aug 15 2018, In: European Journal of Pharmacology. 833, p. 531-544 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

101 Scopus citations

20-HETE: Hypertension and beyond

Roman, R. J. & Fan, F., Jul 1 2018, In: Hypertension. 72, 1, p. 12-18 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

Glial fibrillary acidic protein promoter determines transgene expression in satellite glial cells following intraganglionic adeno-associated virus delivery in adult rats

Xiang, H., Xu, H., Fan, F., Shin, S. M., Hogan, Q. H. & Yu, H., Mar 2018, In: Journal of Neuroscience Research. 96, 3, p. 436-448 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Diffusion-weighted 7.0T Magnetic Resonance Imaging in Assessment of Intervertebral Disc Degeneration in Rats

Li, L. Y., Wu, X. L., Roman, R., Fan, F., Qiu, C. S. & Chen, B. H., Jan 5 2018, In: Chinese Medical Journal. 131, 1, p. 63-68 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Enhanced renal ischemia-reperfusion injury in aging and diabetes

Muroya, Y., He, X., Fan, L., Wang, S., Xu, R., Fan, F. & Roman, R. J., 2018, In: American Journal of Physiology - Renal Physiology. 315, 6, p. F1843-F1854

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

2017

Role of the Primary Cilia on the Macula Densa and Thick Ascending Limbs in Regulation of Sodium Excretion and Hemodynamics

Song, J., Wang, L., Fan, F., Wei, J., Zhang, J., Lu, Y., Fu, Y., Wang, S., Juncos, L. A. & Liu, R., Aug 1 2017, In: Hypertension. 70, 2, p. 324-333 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Impaired myogenic response of the afferent arteriole contributes to the increased susceptibility to renal disease in Milan normotensive rats

Ge, Y., Fan, F., Didion, S. P. & Roman, R. J., Feb 1 2017, In: Physiological reports. 5, 3, e13089.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Knockdown of Add3 impairs the myogenic response of renal afferent arterioles and middle cerebral arteries

Fan, F., Pabbidi, M. R., Ge, Y., Li, L., Wang, S., Mims, P. N. & Roman, R. J., 2017, In: American Journal of Physiology - Renal Physiology. 312, 6, p. F971-F981

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

2016

Macula densa nitric oxide synthase 1b protects against salt-sensitive hypertension

Lu, Y., Wei, J., Stec, D. E., Roman, R. J., Ge, Y., Cheng, L., Liu, E. Y., Zhang, J., Hansen, P. B. L., Fan, F., Juncos, L. A., Wang, L., Pollock, J., Huang, P. L., Fu, Y., Wang, S. & Liu, R., 2016, In: Journal of the American Society of Nephrology. 27, 8, p. 2346-2356 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

2015

Fluorescence dilution technique for measurement of albumin reflection coefficient in isolated glomeruli

Fan, F., Chen, C. C. A., Zhang, J., Schreck, C. M. N., Roman, E. A., Williams, J. M., Hirata, T., Sharma, M., Beard, D. A., Savin, V. J. & Roman, R. J., Dec 15 2015, In: American Journal of Physiology - Renal Physiology. 309, 12, p. F1049-F1059

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Deficiency in the formation of 20-Hydroxyeicosatetraenoic acid enhances renal ischemia-reperfusion injury

Muroya, Y., Fan, F., Regner, K. R., Falck, J. R., Garrett, M. R., Juncos, L. A. & Roman, R. J., Oct 1 2015, In: Journal of the American Society of Nephrology. 26, 10, p. 2460-2469 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4a1 transgenic Dahl salt-sensitive rat

Fan, F., Geurts, A. M., Murphy, S. R., Pabbidi, M. R., Jacob, H. J. & Roman, R. J., 2015, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 308, 5, p. R379-R390

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

2014

Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1^BN rats

Fan, F., Geurts, A. M., Pabbidi, M. R., Smith, S. V., Harder, D. R., Jacob, H. & Roman, R. J., Nov 14 2014, In: PloS one. 9, 11, e112878.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Role of 20-HETE in the impaired myogenic and TGF responses of the Af-Art of Dahl salt-sensitive rats

Ge, Y., Murphy, S. R., Fan, F., Williams, J. M., Falck, J. R., Liu, R. & Roman, R. J., Sep 1 2014, In: American Journal of Physiology - Renal Physiology. 307, 5, p. F509-F515

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Enhanced large conductance K⁺ channel activity contributes to the impaired myogenic response in the cerebral vasculature of Fawn Hooded Hypertensive rats

Pabbidi, M. R., Mazur, O., Fan, F., Farley, J. M., Gebremedhin, D., Harder, D. R. & Roman, R. J., Apr 1 2014, In: American Journal of Physiology - Heart and Circulatory Physiology. 306, 7, p. H989-H1000

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Placental ischemia in pregnant rats impairs cerebral blood flow autoregulation and increases blood-brain barrier permeability

Warrington, J. P., Fan, F., Murphy, S. R., Roman, R. J., Drummond, H. A., Granger, J. P. & Ryan, M. J., 2014, In: Physiological reports. 2, 8, e12134.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

Fan Fan

Research output

Search results