Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Heme-induced metabolic stress drives ferroptosis in sickle cell disease
Zhu, X. (PI)
National Institute of Diabetes and Digestive and Kidney Diseases
9/25/23 → 8/31/26
Project: Research project
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Critical role of NRF2 in globin gene regulation in sickle cell disease mouse models
Zhu, X. (PI)
Project: Research project
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Critical role of NRF2 in globin gene regulation in sickle cell disease mouse models
Zhu, X. (PI)
National Institute of Diabetes and Digestive and Kidney Diseases
9/17/19 → 6/30/22
Project: Research project
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Transsulfuration pathway activation attenuates oxidative stress and ferroptosis in sickle primary erythroblasts and transgenic mice
Xi, C., Pang, J., Xue, W., Cui, Y., Jiang, N., Zhi, W., Shi, H., Horuzsko, A., Pace, B. S. & Zhu, X., Dec 2025, In: Communications Biology. 8, 1, 15.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Innovations in Drug Discovery for Sickle Cell Disease Targeting Oxidative Stress and NRF2 Activation—A Short Review
Starlard-Davenport, A., Palani, C. D., Zhu, X. & Pace, B. S., May 2025, In: International journal of molecular sciences. 26, 9, 4192.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Simvastatin-Mediated Nrf2 Activation Induces Fetal Hemoglobin and Antioxidant Enzyme Expression to Ameliorate the Phenotype of Sickle Cell Disease
Xi, C., Palani, C., Takezaki, M., Shi, H., Horuzsko, A., Pace, B. S. & Zhu, X., Mar 2024, In: Antioxidants. 13, 3, 337.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Bach1 inhibitor HPP-D mediates γ-globin gene activation in sickle erythroid progenitors
Palani, C. D., Zhu, X., Alagar, M., Attucks, O. C. & Pace, B. S., Jan 2024, In: Blood Cells, Molecules, and Diseases. 104, 102792.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Targeting TREM1 augments antitumor T cell immunity by inhibiting myeloid-derived suppressor cells and restraining anti–PD-1 resistance
Ajith, A., Mamouni, K., Horuzsko, D. D., Musa, A., Dzutsev, A. K., Fang, J. R., Chadli, A., Zhu, X., Lebedyeva, I., Trinchieri, G. & Horuzsko, A., Nov 1 2023, In: Journal of Clinical Investigation. 133, 21, e167951.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations