• Buckley, Peter F (PI)
  • Ohmori, Tetsuro (PI)
  • Breslau, Naomi (PI)
  • Ambrosini, Paul (PI)
  • Stockmeier, Craig (PI)
  • Kenny, John (PI)
  • Harrow, Martin (PI)
  • Bastani, Bijan (PI)
  • Vrtunski, P. Bart (PI)
  • Arora, Ramesh (PI)
  • Metz, John (PI)
  • Abel, Larry (PI)
  • Myung, Lee (PI)
  • Emery, Olga (PI)
  • Luchins, Daniel (PI)
  • Sudak, Howard (PI)
  • Sajatovic, Martha (PI)
  • Thompson, Paul (PI)
  • Gudelsky, Gary (PI)
  • Friedman, L.E.E. (PI)
  • Lowy, Martin (PI)
  • Calabrese, Joseph (PI)
  • Nash, J. Frank (PI)
  • Meltzer, Herbert Yale (PI)
  • Gilmore, Grover (PI)
  • Davis, John (PI)
  • Moline, Ronald (PI)
  • Andorn, Anne (PI)
  • Pandey, Ghanshyan (PI)
  • Nasr, Suhayl (PI)
  • Silverstein, Marshall (PI)
  • Alloy, Lauren (PI)
  • Dorus, Elizabeth (PI)
  • Young, Michael (PI)
  • Halaris, Angelos (PI)
  • Mc Cormack, Richard (PI)
  • Chang, Sidney (PI)
  • David, Glenn (PI)
  • Schulz, Charles (PI)

Project: Research project

Project Details


The University of Chicago (UC)-Illinois State Psychiatric Institute (ISPI) MHCRC
provides core resources and pilot study support for a multidisciplinary,
longitudinal study of biology, behavior and psychopathology in schizophrenia,
affective disorders, and the controversial schizoaffective states. The MHCRC
utilizes 30 in-patient research beds and two out-patient clinics at ISPI,
laboratory facilities at ISPI and the UC, and staff from the UC, ISPI, Michael
Reese Hospital, and Northwestern Medical School to conduct its studies and carry
out training functions. Patients are evaluated in standardized manner with an
expanded Present State Examination, SADS-change interviews, a newly developed
Psychiatric History Schedule, as well as other means. A computerized,
multi-system diagnostic approach is integral to a major effort in diagnostic
nosology focused on clarification of the relationship between the so-called
schizoaffective psychoses and the Kraepelinian psychoses. The original MHCRC
emphasis on neuroendocrine (prolactin, growth hormone) and biomedical studies
(platelet MAO, serum CPK, DBH) will be supplemented by new investigators working
in psychophysiology (brain blood flow, laterality, evoked response),
psychopharmacology (peptides, novel anti-depressants lithium), neuropsychology,
virology and biochemistry (receptors for neurotransmitters in platelets and red
blood cells, prostoglandins). Relevant pre-clinical biological studies are also
supported by MHCRC funds. Biological, psychological, and behavioral data
collected at 1, 3, and 5 year follow-up are integrated with data obtained during
initial hospitalization. Family history and family interview studies will also
be conducted in selected areas. Students from every area on clinical practice,
pre- and post-doctoral fellows, and scientists from the U.S. and abroad have
opportunities for intensive research and clinical experiences by participation
in MHCRC projects.
Effective start/end date9/1/858/31/98


  • National Institutes of Health


  • Medicine(all)


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