Overactivation of neuroendocrine and autonomic systems is a common occurrence in prevalent diseases, including salt-dependent hypertension and heart failure. Using a multidisciplinary approach, we propose to investigate mechanisms that mediate activity-dependent neurovascular coupling in the hypothalamus and the impact this process has on neurosecretory neurons that regulate bodily homeostasis in health and disease states. The proposed study will generate novel information on mechanisms underlying altered neuronal function in a heart failure rodent model.
- National Heart, Lung, and Blood Institute: $682,234.00
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