Linking nucleotide and amino acid metabolism to cholesterol synthesis by MYCN

Narrative Metabolic reprogramming by oncogenes and tumor suppressors has a central role in the initiation and progression of cancers, including high-risk neuroblastoma. In this application, we will investigate a new mechanism by which the oncogene MYCN integrates cholesterol synthesis with nucleotide and amino acid metabolism, which may suggest new therapeutic strategies against this deadly pediatric cancer.