Reducing Suicidal Ideation Through Treatment of Nightmares-PTSD (REST-ON-PTSD)

Sleep problems, especially nightmares, have been found to be associated with greater risk of suicidal ideation and behavior. People who suffer from Post-Traumatic Stress Disorder (PTSD) are also at a higher risk to suffer from sleep difficulties caused by nightmares. Dr. McCall's study will look at how Prazosin, a medication to treat nightmares, especially in PTSD, works to reduce suicidal ideation provoked by these nightmares. Forty adults who suffer from PTSD and have a prominent problem with suicidal ideation and nightmares will participate in the study. Participants will be taking a stable dose of an SSRI medication for at least a month before being randomly assigned to treatment with Prazosin or placebo. At the end of eight weeks of treatment, the participants will be assessed to see if their nightmares and suicidal ideation are reduced. A scale for suicide ideation will be used along with measures for PTSD symptoms, depression, nightmares and insomnia.