Project Details
Description
Vascular disease is accompanied by changes in gene expression. SRF binds CArG boxes to direct normal or
abnormal gene expression in cells of the vessel wall called smooth muscle cells. We will use novel tools in
genetics and genomics to define, for the first time, the role of SRF in acute and chronic models of vascular
disease. Findings will inform future therapeutic strategies to combat human vascular diseases.
Status | Not started |
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Funding
- National Heart, Lung, and Blood Institute: $475,562.00
- National Heart, Lung, and Blood Institute: $1,535,720.00
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