Regulation of colitis associated with acute kidney injury by the Wnt pathway

Project Narrative – We have identified a new and previously unsuspected role for the canonical Wnt pathway in antigen presenting cells that is critical for regulating cross‐talk between the gut and kidney during colitis. The proposal focuses on activating the canonical Wnt pathway to suppress renal inflammation and colitis-mediated kidney injury, which may have significant therapeutic impact in treating kidney injury in IBD and other immune- mediated renal diseases.