α-Tocopherol ameliorates cyclophosphamide-induced hyperlipidemia in fibrosarcoma-bearing rats

S. Ilanchezhian; Muthusamy Thangaraju; S. Sasirekha; P. Sachdanandam

doi:10.1097/00001813-199512000-00009

α-Tocopherol ameliorates cyclophosphamide-induced hyperlipidemia in fibrosarcoma-bearing rats

S. Ilanchezhian, Muthusamy Thangaraju, S. Sasirekha, P. Sachdanandam

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Cyclophosphamide, an alkylating agent, is currently being used for the treatment of various types of cancer, either alone or in combination with other cytostatic drugs. However, cyclophosphamide has a detrimental effect on lipid metabolism and causes hyperlipidemia in patients. Since α-tocopherol is known to reduce hyperlipidemia, we have investigated the effects of adding α-tocopherol to the cyclophosphamide treatment. Our study, carried out on fibrosarcoma-bearing rats, shows that α-tocopherol markedly reduces cyclophosphamide-induced hyperlipidemia and brings lipid metabolism down to values observed in untreated controls.

Original language	English (US)
Pages (from-to)	771-774
Number of pages	4
Journal	Anti-Cancer Drugs
Volume	6
Issue number	6
DOIs	https://doi.org/10.1097/00001813-199512000-00009
State	Published - Jan 1 1995
Externally published	Yes

Keywords

Cyclophosphamide
Fibrosarcoma
Lipids
α-Tocopherol

ASJC Scopus subject areas

Oncology
Pharmacology
Pharmacology (medical)
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/00001813-199512000-00009

Cite this

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title = "α-Tocopherol ameliorates cyclophosphamide-induced hyperlipidemia in fibrosarcoma-bearing rats",

abstract = "Cyclophosphamide, an alkylating agent, is currently being used for the treatment of various types of cancer, either alone or in combination with other cytostatic drugs. However, cyclophosphamide has a detrimental effect on lipid metabolism and causes hyperlipidemia in patients. Since α-tocopherol is known to reduce hyperlipidemia, we have investigated the effects of adding α-tocopherol to the cyclophosphamide treatment. Our study, carried out on fibrosarcoma-bearing rats, shows that α-tocopherol markedly reduces cyclophosphamide-induced hyperlipidemia and brings lipid metabolism down to values observed in untreated controls.",

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T1 - α-Tocopherol ameliorates cyclophosphamide-induced hyperlipidemia in fibrosarcoma-bearing rats

AU - Ilanchezhian, S.

AU - Thangaraju, Muthusamy

AU - Sasirekha, S.

AU - Sachdanandam, P.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Cyclophosphamide, an alkylating agent, is currently being used for the treatment of various types of cancer, either alone or in combination with other cytostatic drugs. However, cyclophosphamide has a detrimental effect on lipid metabolism and causes hyperlipidemia in patients. Since α-tocopherol is known to reduce hyperlipidemia, we have investigated the effects of adding α-tocopherol to the cyclophosphamide treatment. Our study, carried out on fibrosarcoma-bearing rats, shows that α-tocopherol markedly reduces cyclophosphamide-induced hyperlipidemia and brings lipid metabolism down to values observed in untreated controls.

AB - Cyclophosphamide, an alkylating agent, is currently being used for the treatment of various types of cancer, either alone or in combination with other cytostatic drugs. However, cyclophosphamide has a detrimental effect on lipid metabolism and causes hyperlipidemia in patients. Since α-tocopherol is known to reduce hyperlipidemia, we have investigated the effects of adding α-tocopherol to the cyclophosphamide treatment. Our study, carried out on fibrosarcoma-bearing rats, shows that α-tocopherol markedly reduces cyclophosphamide-induced hyperlipidemia and brings lipid metabolism down to values observed in untreated controls.

KW - Cyclophosphamide

KW - Fibrosarcoma

KW - Lipids

KW - α-Tocopherol

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ER -

α-Tocopherol ameliorates cyclophosphamide-induced hyperlipidemia in fibrosarcoma-bearing rats

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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