TY - JOUR
T1 - β-Endorphin and essential hypertension
T2 - Importance of the clonidine-naloxone interaction
AU - Farsang, C.
AU - Kapocsi, J.
AU - Varga, K.
AU - Vajda, L.
AU - Balás-Eltes, A.
AU - Kunos, G.
PY - 1985/10/10
Y1 - 1985/10/10
N2 - Analysis of the effect of naloxone (0.4 mg iv.) on clonidine hypotension in 80 patients with essential hypertension revealed that two groups could be separated. In the responding group (43 pts) naloxone increased blood pressure and heart rate in clonidine-treated patients while in the non-responding group (37 pts) it has no such effect. Patients in the responding group had higher cardiac output, stroke volume, plasma renin activity, plasma adrenaline and β-endorphin levels and lower total peripheral resistance, shorter history of hypertension and lower body weight than those in the non-responding group. The pressor effect of naloxone in four responding patients treated with clonidine for 29 months tended to be smaller compared to the response obtained after a 3-day clonidine therapy. Results favour the hypothesis of the existence of two (responding, non-responding) groups of patients with essential hypertension. Further work will clarify whether these groups represent different pathogenesis or indicate only a different stage of hypertension.
AB - Analysis of the effect of naloxone (0.4 mg iv.) on clonidine hypotension in 80 patients with essential hypertension revealed that two groups could be separated. In the responding group (43 pts) naloxone increased blood pressure and heart rate in clonidine-treated patients while in the non-responding group (37 pts) it has no such effect. Patients in the responding group had higher cardiac output, stroke volume, plasma renin activity, plasma adrenaline and β-endorphin levels and lower total peripheral resistance, shorter history of hypertension and lower body weight than those in the non-responding group. The pressor effect of naloxone in four responding patients treated with clonidine for 29 months tended to be smaller compared to the response obtained after a 3-day clonidine therapy. Results favour the hypothesis of the existence of two (responding, non-responding) groups of patients with essential hypertension. Further work will clarify whether these groups represent different pathogenesis or indicate only a different stage of hypertension.
UR - http://www.scopus.com/inward/record.url?scp=0021996498&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021996498&partnerID=8YFLogxK
M3 - Article
C2 - 3157294
AN - SCOPUS:0021996498
SN - 0231-424X
VL - 65
SP - 217
EP - 226
JO - Acta Physiologica Hungarica
JF - Acta Physiologica Hungarica
IS - 2
ER -