TY - JOUR
T1 - A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth
T2 - 25-Hydroxyvitamin D, adiposity, and arterial stiffness
AU - Dong, Yanbin
AU - Stallmann-Jorgensen, Inger S.
AU - Pollock, Norman K.
AU - Harris, Ryan A.
AU - Keeton, Daniel
AU - Huang, Ying
AU - Li, Ke
AU - Bassali, Reda W
AU - Guo, De Huang
AU - Thomas, Jeffrey
AU - Pierce, Gary L.
AU - White, Jennifer
AU - Holick, Michael F.
AU - Zhu, Haidong
N1 - Funding Information:
This work was supported by an intramural grant of the Diabetes and Obesity Discovery Institute at the Medical College of Georgia. Cholecalciferol (vitamin D 3 ) is available over the counter, and we purchased it online. The company had no role in the study design, study conduct, data collection or analysis, interpretation of the data, or preparation, review, or approval of the manuscript.
PY - 2010/10
Y1 - 2010/10
N2 - Context: Vitamin D insufficiency/deficiency is commonly observed in black youth. Objective: The aim was to determine 25-hydroxyvitamin D [25(OH)D] in response to 2000 IU vitamin D supplementation over time; to evaluate the relation between 25(OH)D concentrations and total body fat mass by dual-energy x-ray absorptiometry; and to determine whether vitamin D supplementation improves arterial stiffness measured by pulse wave velocity (PWV). Design: We conducted a randomized, blinded, controlled clinical trial. Setting and Participants: Forty-nine normotensive black boys and girls, aged 16.3 ± 1.4 yr, were randomly assigned to either the control group (400 IU/d; n = 24) or the experimental group (2000 IU/d; n = 25). Results: Plasma 25(OH)D values at baseline and at 4, 8, and 16 wk were 34.0 ± 10.6, 44.9 ± 9.4, 51.2 ± 11.1, and 59.8 ± 18.2 nmol/liter, respectively, for the control group; and 33.1 ± 8.7, 55.0 ± 11.8, 70.9 ± 22.0, and 85.7 ± 30.1 nmol/liter, respectively, for the experimental group. The experimental group vs. the control group reached significantly higher 25(OH)D concentrations at 8 and 16 wk, respectively. Partial correlation analyses indicated that total body fat mass at baseline was significantly and inversely associated with 25(OH)D concentrations in response to the 2000-IU supplement across time. Furthermore, carotid-femoral PWV increased from baseline (5.38 ± 0.53 m/sec) to posttest (5.71 ± 0.75 m/sec) in the control group (P = 0.016), whereas in the experimental group carotid-femoral PWV decreased from baseline (5.41 ± 0.73 m/sec) to posttest (5.33 ± 0.79 m/sec) (P = 0.031). Conclusion: Daily 2000 IU vitamin D supplementation may be effective in optimizing vitamin D status and counteracting the progression of aortic stiffness in black youth. Plasma 25(OH)D concentrations in response to the 2000 IU/d supplementation are negatively modulated by adiposity.
AB - Context: Vitamin D insufficiency/deficiency is commonly observed in black youth. Objective: The aim was to determine 25-hydroxyvitamin D [25(OH)D] in response to 2000 IU vitamin D supplementation over time; to evaluate the relation between 25(OH)D concentrations and total body fat mass by dual-energy x-ray absorptiometry; and to determine whether vitamin D supplementation improves arterial stiffness measured by pulse wave velocity (PWV). Design: We conducted a randomized, blinded, controlled clinical trial. Setting and Participants: Forty-nine normotensive black boys and girls, aged 16.3 ± 1.4 yr, were randomly assigned to either the control group (400 IU/d; n = 24) or the experimental group (2000 IU/d; n = 25). Results: Plasma 25(OH)D values at baseline and at 4, 8, and 16 wk were 34.0 ± 10.6, 44.9 ± 9.4, 51.2 ± 11.1, and 59.8 ± 18.2 nmol/liter, respectively, for the control group; and 33.1 ± 8.7, 55.0 ± 11.8, 70.9 ± 22.0, and 85.7 ± 30.1 nmol/liter, respectively, for the experimental group. The experimental group vs. the control group reached significantly higher 25(OH)D concentrations at 8 and 16 wk, respectively. Partial correlation analyses indicated that total body fat mass at baseline was significantly and inversely associated with 25(OH)D concentrations in response to the 2000-IU supplement across time. Furthermore, carotid-femoral PWV increased from baseline (5.38 ± 0.53 m/sec) to posttest (5.71 ± 0.75 m/sec) in the control group (P = 0.016), whereas in the experimental group carotid-femoral PWV decreased from baseline (5.41 ± 0.73 m/sec) to posttest (5.33 ± 0.79 m/sec) (P = 0.031). Conclusion: Daily 2000 IU vitamin D supplementation may be effective in optimizing vitamin D status and counteracting the progression of aortic stiffness in black youth. Plasma 25(OH)D concentrations in response to the 2000 IU/d supplementation are negatively modulated by adiposity.
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U2 - 10.1210/jc.2010-0606
DO - 10.1210/jc.2010-0606
M3 - Article
C2 - 20660028
AN - SCOPUS:77957800242
SN - 0021-972X
VL - 95
SP - 4584
EP - 4591
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 10
ER -