Abstract
A procedure for the cyclization of dipeptidoyl benzotriazolides containing proline derivatives promoted by triethylamine under MW activation is introduced. The reaction is general for a variety of dipeptidoyl benzotriazolides and represents a very practical and convenient method for the preparation of Pro- or Hyp-derived 2,5-diketopiperazines (2,5-DKPs) and bis-DKPs with a disulfide linker. This method can be used for the construction of 2,5-DKP compound libraries and for the synthesis of natural products with diketopiperazine cores.
Original language | English (US) |
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Pages (from-to) | 4399-403 |
Number of pages | 5 |
Journal | Organic and Biomolecular Chemistry |
Volume | 13 |
Issue number | 15 |
DOIs | |
State | Published - Apr 21 2015 |
Keywords
- Animals
- Biological Products
- Cyclization
- Diketopiperazines
- Dipeptides
- Ethylamines
- Porifera
- Proline
- Stereoisomerism
- Triazoles
- Journal Article
- Research Support, Non-U.S. Gov't