A biochemical approach to periodontal regeneration: Tetracycline treatment of dentin promotes fibroblast adhesion and growth

V. P. Terranova; L. C. Franzetti; S. Hic; R. M. DiFlorio; R. M. Lyall; U. M. Wikesjö; P. J. Baker; L. A. Christersson; R. J. Genco

doi:10.1111/j.1600-0765.1986.tb01467.x

A biochemical approach to periodontal regeneration: Tetracycline treatment of dentin promotes fibroblast adhesion and growth

V. P. Terranova, L. C. Franzetti, S. Hic, R. M. DiFlorio, R. M. Lyall, U. M. Wikesjö, P. J. Baker, L. A. Christersson, R. J. Genco

Periodontics

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Abstract

One objective of periodontal therapy after resolution of the infectious process is to facilitate a new connective tissue attachment to the root dentin surface. Here we report that a selective advantage for attachment and growth can be conferred on human gingival fibroblasts by biochemical manipulation of the dentin surface. Tetracycline HCL treatment of the dentin surface increases binding of fibronectin. The adsorbed fibronectin stimulates fibroblast attachment and growth, while suppressing epithelial cell attachment and growth. This biochemical manipulation may provide a useful approach for the treatment of periodontally involved teeth.

Original language	English (US)
Pages (from-to)	330-337
Number of pages	8
Journal	Journal of Periodontal Research
Volume	21
Issue number	4
DOIs	https://doi.org/10.1111/j.1600-0765.1986.tb01467.x
State	Published - Jul 1986

ASJC Scopus subject areas

Periodontics

Access to Document

10.1111/j.1600-0765.1986.tb01467.x

Cite this

Terranova, V. P., Franzetti, L. C., Hic, S., DiFlorio, R. M., Lyall, R. M., Wikesjö, U. M., Baker, P. J., Christersson, L. A., & Genco, R. J. (1986). A biochemical approach to periodontal regeneration: Tetracycline treatment of dentin promotes fibroblast adhesion and growth. Journal of Periodontal Research, 21(4), 330-337. https://doi.org/10.1111/j.1600-0765.1986.tb01467.x

@article{97de4439532242c989d5fca8b982a030,

title = "A biochemical approach to periodontal regeneration: Tetracycline treatment of dentin promotes fibroblast adhesion and growth",

abstract = "One objective of periodontal therapy after resolution of the infectious process is to facilitate a new connective tissue attachment to the root dentin surface. Here we report that a selective advantage for attachment and growth can be conferred on human gingival fibroblasts by biochemical manipulation of the dentin surface. Tetracycline HCL treatment of the dentin surface increases binding of fibronectin. The adsorbed fibronectin stimulates fibroblast attachment and growth, while suppressing epithelial cell attachment and growth. This biochemical manipulation may provide a useful approach for the treatment of periodontally involved teeth.",

author = "Terranova, {V. P.} and Franzetti, {L. C.} and S. Hic and DiFlorio, {R. M.} and Lyall, {R. M.} and Wikesj{\"o}, {U. M.} and Baker, {P. J.} and Christersson, {L. A.} and Genco, {R. J.}",

year = "1986",

month = jul,

doi = "10.1111/j.1600-0765.1986.tb01467.x",

language = "English (US)",

volume = "21",

pages = "330--337",

journal = "Journal of Periodontal Research",

issn = "0022-3484",

publisher = "Blackwell Munksgaard",

number = "4",

}

TY - JOUR

T1 - A biochemical approach to periodontal regeneration

T2 - Tetracycline treatment of dentin promotes fibroblast adhesion and growth

AU - Terranova, V. P.

AU - Franzetti, L. C.

AU - Hic, S.

AU - DiFlorio, R. M.

AU - Lyall, R. M.

AU - Wikesjö, U. M.

AU - Baker, P. J.

AU - Christersson, L. A.

AU - Genco, R. J.

PY - 1986/7

Y1 - 1986/7

N2 - One objective of periodontal therapy after resolution of the infectious process is to facilitate a new connective tissue attachment to the root dentin surface. Here we report that a selective advantage for attachment and growth can be conferred on human gingival fibroblasts by biochemical manipulation of the dentin surface. Tetracycline HCL treatment of the dentin surface increases binding of fibronectin. The adsorbed fibronectin stimulates fibroblast attachment and growth, while suppressing epithelial cell attachment and growth. This biochemical manipulation may provide a useful approach for the treatment of periodontally involved teeth.

AB - One objective of periodontal therapy after resolution of the infectious process is to facilitate a new connective tissue attachment to the root dentin surface. Here we report that a selective advantage for attachment and growth can be conferred on human gingival fibroblasts by biochemical manipulation of the dentin surface. Tetracycline HCL treatment of the dentin surface increases binding of fibronectin. The adsorbed fibronectin stimulates fibroblast attachment and growth, while suppressing epithelial cell attachment and growth. This biochemical manipulation may provide a useful approach for the treatment of periodontally involved teeth.

UR - http://www.scopus.com/inward/record.url?scp=0022992076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022992076&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0765.1986.tb01467.x

DO - 10.1111/j.1600-0765.1986.tb01467.x

M3 - Article

C2 - 2942661

AN - SCOPUS:0022992076

SN - 0022-3484

VL - 21

SP - 330

EP - 337

JO - Journal of Periodontal Research

JF - Journal of Periodontal Research

IS - 4

ER -

A biochemical approach to periodontal regeneration: Tetracycline treatment of dentin promotes fibroblast adhesion and growth

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this