A double-blind comparison of three dosages of flutroline (CP-36,584) in the treatment of schizophrenia

J. P. McEvoy; S. Berney; W. H. Wilson; T. A. Ban; W. Guy

doi:10.1159/000468455

A double-blind comparison of three dosages of flutroline (CP-36,584) in the treatment of schizophrenia

J. P. McEvoy, S. Berney, W. H. Wilson, T. A. Ban, W. Guy

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Therapeutic and adverse effects of three dosages (1, 20 and 100 mg daily) of flutroline, a new γ-carboline with a preclinical pharmacological profile similar to active neuroleptic agents, were compared in a double-blind clinical trial in 25 newly-admitted schizophrenic patients. Therapeutic effects and extrapyramidal signs were seen at the 20 and 100-mg daily dosages, but not at the 1-mg dosage. Serum prolactin levels were significantly elevated only at the 100-mg daily dose.

Original language	English (US)
Pages (from-to)	318-324
Number of pages	7
Journal	Unknown Journal
Volume	15
Issue number	5
DOIs	https://doi.org/10.1159/000468455
State	Published - Jan 1 1980
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1159/000468455

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AU - Berney, S.

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AU - Ban, T. A.

AU - Guy, W.

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AB - Therapeutic and adverse effects of three dosages (1, 20 and 100 mg daily) of flutroline, a new γ-carboline with a preclinical pharmacological profile similar to active neuroleptic agents, were compared in a double-blind clinical trial in 25 newly-admitted schizophrenic patients. Therapeutic effects and extrapyramidal signs were seen at the 20 and 100-mg daily dosages, but not at the 1-mg dosage. Serum prolactin levels were significantly elevated only at the 100-mg daily dose.

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A double-blind comparison of three dosages of flutroline (CP-36,584) in the treatment of schizophrenia

Abstract

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