TY - JOUR
T1 - A first case of hepatocellular carcinoma in the baboon (Papio spp.) placenta
AU - Schlabritz-Loutsevitch, Natalia
AU - Carrillo, Maira
AU - Li, Cun
AU - Nathanielsz, Peter
AU - Maguire, Christopher
AU - Maher, James
AU - Dick, Edward
AU - Hubbard, Gene
AU - Stanek, Jerzy
N1 - Publisher Copyright:
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2019/2
Y1 - 2019/2
N2 - We present a case of hepatocellular carcinoma (HCC) in the placenta of healthy baboon (Papio spp.). Grossly, the fetal, maternal, and placental tissues were unremarkable. Histologically, the placenta contained an unencapsulated, poorly demarcated, infiltrative, solidly cellular neoplasm composed of cells that resembled hepatocytes. The neoplastic cells were diffusely positive for vimentin and focally positive for Ae1/Ae3, Arginase -1, glutamine synthetase, and CD10, and negative for ER, vascular markers (CD31 and D240), S100, glypican, C-reactive protein, FABP, desmin, and beta-catenin; INI1 positivity was similar to non-neoplastic tissues. The case likely represents a unique subtype of HCC.
AB - We present a case of hepatocellular carcinoma (HCC) in the placenta of healthy baboon (Papio spp.). Grossly, the fetal, maternal, and placental tissues were unremarkable. Histologically, the placenta contained an unencapsulated, poorly demarcated, infiltrative, solidly cellular neoplasm composed of cells that resembled hepatocytes. The neoplastic cells were diffusely positive for vimentin and focally positive for Ae1/Ae3, Arginase -1, glutamine synthetase, and CD10, and negative for ER, vascular markers (CD31 and D240), S100, glypican, C-reactive protein, FABP, desmin, and beta-catenin; INI1 positivity was similar to non-neoplastic tissues. The case likely represents a unique subtype of HCC.
KW - baboon
KW - hepatocellular carcinoma
KW - non-human primates
KW - placenta
UR - http://www.scopus.com/inward/record.url?scp=85053729350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053729350&partnerID=8YFLogxK
U2 - 10.1111/jmp.12382
DO - 10.1111/jmp.12382
M3 - Article
C2 - 30246873
AN - SCOPUS:85053729350
SN - 0047-2565
VL - 48
SP - 68
EP - 73
JO - Journal of medical primatology
JF - Journal of medical primatology
IS - 1
ER -