A hyaluronate based gel for the prevention of postsurgical adhesions: Evaluation in two animal species

J. W. Burns, K. Skinner, M. J. Colt, L. Burgess, R. Rose, M. P. Diamond

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Objective: To assess in two animal surgery models, the efficacy of a bioabsorbable gel to prevent postoperative adhesions. Design: A randomized, prospective, blinded study using animal abdominal surgery models. Setting: Two animals species with surgical traumas to induce adhesion formation. Interventions: A chemically modified hyaluronate and carboxymethylcellulose- based gel formulation. Main Outcome Measures: The number of animals with no adhesions, mean number of adhesions, and total adhesion score. Results: Treatment with the bioabsorbable gel increased the number of animals without any adhesion by 70% in a rat cecal abrasion model and by >90% in a rabbit sidewall defect-bowel abrasion model when compared with nontreatment control animals. Other outcome measures showed similar efficacy. Conclusion: The modified hyaluronate-carboxymethylcellulose gel was effective in two animal species after surgery in the abdominal cavity. The gel appears to act as a physical harrier between damaged peritoneal tissue and may be appropriate for human clinical trials in open and laparoscopic surgical procedures.

Original languageEnglish (US)
Pages (from-to)814-821
Number of pages8
JournalFertility and sterility
Issue number5
StatePublished - 1996
Externally publishedYes


  • Postsurgical adhesions
  • adhesion prevention
  • hyaluronate gel

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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