A hypothesis concerning the general basis of organogenetic congenital anomalies

Frederick Naftolin; Michael P. Diamond; Emese Pinter; E. Albert Reece; M. K. Sanyal

doi:10.1016/S0002-9378(87)80332-0

A hypothesis concerning the general basis of organogenetic congenital anomalies

Frederick Naftolin
, Michael P. Diamond
, Emese Pinter
, E. Albert Reece
, M. K. Sanyal

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Evidence supports the idea that it is the degree of metabolic imbalance present in diabetic gravid women during the period of organogenesis that accounts for organogenetic congenital defects. In light of the proved and inferred metabolic instability occurring during early pregnancy, we propose that metabolic imbalances may occur that result in organogenetic congenital defects in offspring of apparently normal gravid women.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	American journal of obstetrics and gynecology
Volume	157
Issue number	1
DOIs	https://doi.org/10.1016/S0002-9378(87)80332-0
State	Published - 1987
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Organogenesis
birth defect
diabetes mellitus

ASJC Scopus subject areas

Obstetrics and Gynecology

Access to Document

10.1016/S0002-9378(87)80332-0

Cite this

@article{44aaced9a9c8443ca896baf1d237c0b0,

title = "A hypothesis concerning the general basis of organogenetic congenital anomalies",

abstract = "Evidence supports the idea that it is the degree of metabolic imbalance present in diabetic gravid women during the period of organogenesis that accounts for organogenetic congenital defects. In light of the proved and inferred metabolic instability occurring during early pregnancy, we propose that metabolic imbalances may occur that result in organogenetic congenital defects in offspring of apparently normal gravid women.",

keywords = "Organogenesis, birth defect, diabetes mellitus",

author = "Frederick Naftolin and Diamond, \{Michael P.\} and Emese Pinter and Reece, \{E. Albert\} and Sanyal, \{M. K.\}",

note = "Funding Information: From the Department of Obstetrics and Gynecology, Yale University School of Medicine. Supported by the March of Dimes Birth Defects Foundation, the Ju-venile Diabetes Foundation, the American Diabetes Foundation, and the National Institutes of Health. Presented in part at the Obstetrical Society of Philadelphia, March 13, 1986. Reprint requests: Frederick Naftolin, M.D., D.Phil., Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar St. PO Box 3333, New Haven, CT 06510-8063. *Mellon Fellow in the Reproductive Sciences. **James Hudson Brown Scholar.",

year = "1987",

doi = "10.1016/S0002-9378(87)80332-0",

language = "English (US)",

volume = "157",

pages = "1--4",

journal = "American journal of obstetrics and gynecology",

issn = "0002-9378",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - A hypothesis concerning the general basis of organogenetic congenital anomalies

AU - Naftolin, Frederick

AU - Diamond, Michael P.

AU - Pinter, Emese

AU - Reece, E. Albert

AU - Sanyal, M. K.

N1 - Funding Information: From the Department of Obstetrics and Gynecology, Yale University School of Medicine. Supported by the March of Dimes Birth Defects Foundation, the Ju-venile Diabetes Foundation, the American Diabetes Foundation, and the National Institutes of Health. Presented in part at the Obstetrical Society of Philadelphia, March 13, 1986. Reprint requests: Frederick Naftolin, M.D., D.Phil., Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar St. PO Box 3333, New Haven, CT 06510-8063. *Mellon Fellow in the Reproductive Sciences. **James Hudson Brown Scholar.

PY - 1987

Y1 - 1987

N2 - Evidence supports the idea that it is the degree of metabolic imbalance present in diabetic gravid women during the period of organogenesis that accounts for organogenetic congenital defects. In light of the proved and inferred metabolic instability occurring during early pregnancy, we propose that metabolic imbalances may occur that result in organogenetic congenital defects in offspring of apparently normal gravid women.

AB - Evidence supports the idea that it is the degree of metabolic imbalance present in diabetic gravid women during the period of organogenesis that accounts for organogenetic congenital defects. In light of the proved and inferred metabolic instability occurring during early pregnancy, we propose that metabolic imbalances may occur that result in organogenetic congenital defects in offspring of apparently normal gravid women.

KW - Organogenesis

KW - birth defect

KW - diabetes mellitus

UR - https://www.scopus.com/pages/publications/0023275615

UR - https://www.scopus.com/pages/publications/0023275615#tab=citedBy

U2 - 10.1016/S0002-9378(87)80332-0

DO - 10.1016/S0002-9378(87)80332-0

M3 - Article

C2 - 3605239

AN - SCOPUS:0023275615

SN - 0002-9378

VL - 157

SP - 1

EP - 4

JO - American journal of obstetrics and gynecology

JF - American journal of obstetrics and gynecology

IS - 1

ER -

A hypothesis concerning the general basis of organogenetic congenital anomalies

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this