A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10

C. G.P. Mathew; K. S. Chin; D. F. Easton; K. Thorpe; C. Carter; Gregory I Liou; S. L. Fong; C. D.B. Bridges; H. Haak; A. C.Nieuwenhuijzen Kruseman; S. Schifter; H. H. Hansen; H. Telenius; M. Telenius-Berg; B. A.J. Ponder

doi:10.1038/328527a0

A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10

C. G.P. Mathew
, K. S. Chin
, D. F. Easton
, K. Thorpe
, C. Carter
, Gregory I Liou
, S. L. Fong
, C. D.B. Bridges
, H. Haak
, A. C.Nieuwenhuijzen Kruseman
, S. Schifter
, H. H. Hansen
, H. Telenius
, M. Telenius-Berg
, B. A.J. Ponder

Graduate Studies

Research output: Contribution to journal › Article › peer-review

391 Scopus citations

Abstract

Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominantly inherited cancer syndrome characterized by medullary carcinoma of the thyroid, phaeochromocytoma and hyperparathyroidism. Almost all gene carriers can be detected by screening tests before the age of 40 (ref. 1), but the nature and location of the predisposing gene are unknown. Simpson et al.² recently reported preliminary evidence for linkage between the DNA probe p9-12A on chromosome 10 and MEN2A. We now report linkage between the MEN2A locus and the interstitial retinol-binding protein gene, which is located on chromosome 10p11.2-q11.2 (ref. 3).

Original language	English (US)
Pages (from-to)	527-528
Number of pages	2
Journal	Nature
Volume	328
Issue number	6130
DOIs	https://doi.org/10.1038/328527a0
State	Published - 1987

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SDG 3 Good Health and Well-being

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Mathew, C. G. P., Chin, K. S., Easton, D. F., Thorpe, K., Carter, C., Liou, G. I., Fong, S. L., Bridges, C. D. B., Haak, H., Kruseman, A. C. N., Schifter, S., Hansen, H. H., Telenius, H., Telenius-Berg, M., & Ponder, B. A. J. (1987). A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10. Nature, 328(6130), 527-528. https://doi.org/10.1038/328527a0

@article{2cbecb4158404f6c970a00b2e873414c,

title = "A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10",

abstract = "Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominantly inherited cancer syndrome characterized by medullary carcinoma of the thyroid, phaeochromocytoma and hyperparathyroidism. Almost all gene carriers can be detected by screening tests before the age of 40 (ref. 1), but the nature and location of the predisposing gene are unknown. Simpson et al.2 recently reported preliminary evidence for linkage between the DNA probe p9-12A on chromosome 10 and MEN2A. We now report linkage between the MEN2A locus and the interstitial retinol-binding protein gene, which is located on chromosome 10p11.2-q11.2 (ref. 3).",

author = "Mathew, \{C. G.P.\} and Chin, \{K. S.\} and Easton, \{D. F.\} and K. Thorpe and C. Carter and Liou, \{Gregory I\} and Fong, \{S. L.\} and Bridges, \{C. D.B.\} and H. Haak and Kruseman, \{A. C.Nieuwenhuijzen\} and S. Schifter and Hansen, \{H. H.\} and H. Telenius and M. Telenius-Berg and Ponder, \{B. A.J.\}",

year = "1987",

doi = "10.1038/328527a0",

language = "English (US)",

volume = "328",

pages = "527--528",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "6130",

}

TY - JOUR

T1 - A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10

AU - Mathew, C. G.P.

AU - Chin, K. S.

AU - Easton, D. F.

AU - Thorpe, K.

AU - Carter, C.

AU - Liou, Gregory I

AU - Fong, S. L.

AU - Bridges, C. D.B.

AU - Haak, H.

AU - Kruseman, A. C.Nieuwenhuijzen

AU - Schifter, S.

AU - Hansen, H. H.

AU - Telenius, H.

AU - Telenius-Berg, M.

AU - Ponder, B. A.J.

PY - 1987

Y1 - 1987

N2 - Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominantly inherited cancer syndrome characterized by medullary carcinoma of the thyroid, phaeochromocytoma and hyperparathyroidism. Almost all gene carriers can be detected by screening tests before the age of 40 (ref. 1), but the nature and location of the predisposing gene are unknown. Simpson et al.2 recently reported preliminary evidence for linkage between the DNA probe p9-12A on chromosome 10 and MEN2A. We now report linkage between the MEN2A locus and the interstitial retinol-binding protein gene, which is located on chromosome 10p11.2-q11.2 (ref. 3).

AB - Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominantly inherited cancer syndrome characterized by medullary carcinoma of the thyroid, phaeochromocytoma and hyperparathyroidism. Almost all gene carriers can be detected by screening tests before the age of 40 (ref. 1), but the nature and location of the predisposing gene are unknown. Simpson et al.2 recently reported preliminary evidence for linkage between the DNA probe p9-12A on chromosome 10 and MEN2A. We now report linkage between the MEN2A locus and the interstitial retinol-binding protein gene, which is located on chromosome 10p11.2-q11.2 (ref. 3).

UR - https://www.scopus.com/pages/publications/0023229266

UR - https://www.scopus.com/pages/publications/0023229266#tab=citedBy

U2 - 10.1038/328527a0

DO - 10.1038/328527a0

M3 - Article

C2 - 2886917

AN - SCOPUS:0023229266

SN - 0028-0836

VL - 328

SP - 527

EP - 528

JO - Nature

JF - Nature

IS - 6130

ER -

A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10

Abstract

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