TY - JOUR
T1 - A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India
AU - Manoharan, Indumathi
AU - Boopathy, Rathnam
AU - Darvesh, Sultan
AU - Lockridge, Oksana
N1 - Funding Information:
This work was supported by the Indian funding agency, AICTE, New Delhi Grant F. No 8019/RDII/BOR/R&D 226/2001 (to RB), IM was funded by a Research Fellowship from Bharathiar University, contracts W81XWH-06–1-0102 and W911SR-04-C-0019 from the US Department of Defense (to OL), the Canadian Institutes of Health Research, Nova Scotia Health Research Foundation, Capital District Health Authority Research Fund, Heart and Stroke Foundation of Nova Scotia, Canada and the Brain Tumour Foundation of Canada (to SD).
PY - 2007/3
Y1 - 2007/3
N2 - Background: Butyrylcholinesterase (BChE; gi:116353) deficiency has adverse effects on the response to succinylcholine and mivacurium. A physiological function of BChE is to inactivate octanoyl ghrelin. We determined the health effect of complete absence of BChE in humans. Methods: Clinical tests of cardiac, lung, liver, and kidney function, body weight, sperm counts and motility were performed on 5 men, age 20-32 y, in the Vysya community of Coimbatore, India who had silent BChE. Postmortem tissues from 2 cadavers with wild-type BChE were assayed. Results: Test results were normal, except for lung function, which indicated mild obstruction in silent as well as in wild-type BChE subjects. Creatine kinase-MB levels were high in 2 subjects, but there were no other indications of damage to the heart. Body weight was normal. Family histories revealed no trend in disease susceptibility. The human body contains 10 times more BChE than acetylcholinesterase molecules. Conclusion: Individuals completely deficient in BChE have only minor abnormalities in clinical test results. However, they respond abnormally to standard doses of succinylcholine and mivacurium. It is expected, but not proven, that they are unusually susceptible to the toxicity of cocaine and organophosphorus pesticides, and resistant to bambuterol and irinotecan. Their normal body weight suggests alternative routes for deactivation of octanoyl ghrelin.
AB - Background: Butyrylcholinesterase (BChE; gi:116353) deficiency has adverse effects on the response to succinylcholine and mivacurium. A physiological function of BChE is to inactivate octanoyl ghrelin. We determined the health effect of complete absence of BChE in humans. Methods: Clinical tests of cardiac, lung, liver, and kidney function, body weight, sperm counts and motility were performed on 5 men, age 20-32 y, in the Vysya community of Coimbatore, India who had silent BChE. Postmortem tissues from 2 cadavers with wild-type BChE were assayed. Results: Test results were normal, except for lung function, which indicated mild obstruction in silent as well as in wild-type BChE subjects. Creatine kinase-MB levels were high in 2 subjects, but there were no other indications of damage to the heart. Body weight was normal. Family histories revealed no trend in disease susceptibility. The human body contains 10 times more BChE than acetylcholinesterase molecules. Conclusion: Individuals completely deficient in BChE have only minor abnormalities in clinical test results. However, they respond abnormally to standard doses of succinylcholine and mivacurium. It is expected, but not proven, that they are unusually susceptible to the toxicity of cocaine and organophosphorus pesticides, and resistant to bambuterol and irinotecan. Their normal body weight suggests alternative routes for deactivation of octanoyl ghrelin.
KW - Butyrylcholinesterase deficiency
KW - Ghrelin
KW - Mivacurium
KW - Succinylcholine
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U2 - 10.1016/j.cca.2006.11.005
DO - 10.1016/j.cca.2006.11.005
M3 - Article
C2 - 17182021
AN - SCOPUS:33846969163
SN - 0009-8981
VL - 378
SP - 128
EP - 135
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
IS - 1-2
ER -