Abstract
Double minute chromosomes (DMs) are reported for the first time in in vitro transformed mouse epithelial cells. In one cell line, CSG 122/17, DMs persisted through numerous passages. A subpopulation appeared in this line at passage 23, in which the DMs had disappeared but were replaced by a finely banded chromosome region possibly associated with the distal end of chromosome 5. In a second cell line, CSG 120/7, there was no evidence of DMs in the earliest frozen stock available. However, a finely banded region similar to that found in CSG 122/17 was present and was again associated with chromosome 5, in this case with the proximal end. The possible evolution of these new chromosome regions from DMs is discussed.
Original language | English (US) |
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Pages (from-to) | 2-7 |
Number of pages | 6 |
Journal | Cytogenetics and Cell Genetics |
Volume | 27 |
Issue number | 1 |
DOIs | |
State | Published - 1980 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Cell Biology