A non-penetrating thiol reagent mimics cytochalasin a inhibition of secretory protein synthesis

Elias K. Manavathu; Donovan des S. Thomas

doi:10.1016/0006-291X(76)90279-5

A non-penetrating thiol reagent mimics cytochalasin a inhibition of secretory protein synthesis

Elias K. Manavathu, Donovan des S. Thomas

Research output: Contribution to journal › Article › peer-review

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Abstract

Mimicry of selective cytochalasin A (CA) inhibition of cellulase synthesis in the water mold Achlya by the non-penetrating thiol reagent, p-chloromercuribenzene sulphonate suggests that CA may act as a non-permeant sulphydryl reagent, and that inhibition of cellulase synthesis may be exerted via relatively superficial thiol groups in the plasma membrane.

Original language	English (US)
Pages (from-to)	280-285
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	71
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(76)90279-5
State	Published - Jul 12 1976
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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abstract = "Mimicry of selective cytochalasin A (CA) inhibition of cellulase synthesis in the water mold Achlya by the non-penetrating thiol reagent, p-chloromercuribenzene sulphonate suggests that CA may act as a non-permeant sulphydryl reagent, and that inhibition of cellulase synthesis may be exerted via relatively superficial thiol groups in the plasma membrane.",

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AU - Thomas, Donovan des S.

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N2 - Mimicry of selective cytochalasin A (CA) inhibition of cellulase synthesis in the water mold Achlya by the non-penetrating thiol reagent, p-chloromercuribenzene sulphonate suggests that CA may act as a non-permeant sulphydryl reagent, and that inhibition of cellulase synthesis may be exerted via relatively superficial thiol groups in the plasma membrane.

AB - Mimicry of selective cytochalasin A (CA) inhibition of cellulase synthesis in the water mold Achlya by the non-penetrating thiol reagent, p-chloromercuribenzene sulphonate suggests that CA may act as a non-permeant sulphydryl reagent, and that inhibition of cellulase synthesis may be exerted via relatively superficial thiol groups in the plasma membrane.

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A non-penetrating thiol reagent mimics cytochalasin a inhibition of secretory protein synthesis

Abstract

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