A noninvasive multimodal sono-contrast NIR spectroscopy system for breast cancer diagnosis

Kaiguo Yan; Tarun Podder; Ke Huang; Yan Yu; Lydia Liao

doi:10.1109/BIBE.2010.55

A noninvasive multimodal sono-contrast NIR spectroscopy system for breast cancer diagnosis

Kaiguo Yan
, Tarun Podder
, Ke Huang
, Yan Yu
, Lydia Liao

Medical Laboratory, Imaging and Radiologic Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

We have developed a multimodal imaging system that combines three modalities, optical spectroscopy, ultrasonography and acoustic radiation force (ARF) for improving diagnosis of breast cancer based on noninvasive interrogation of vasculature. This paper presents a detailed system design. The safety issues regarding the use of laser and ultrasound have also been addressed in this paper. The maximum exposure to skin for laser was controlled within 0.2 W·cm^-2 (ANSI Z136.1); exposure from ARF fields were maintained below the FDA diagnostic limit (0.72 W·cm^-2). This multimodal system has the potential to improve tumor detection by deploying ARF to produce a measurable difference in the dynamic behavior of the tissue blood supply environment as interrogated by optical spectroscopy, which was demonstrated to be highly diagnostic in a murine tumor model. Pilot clinical study is being carried out.

Original language	English (US)
Title of host publication	10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010
Pages	285-286
Number of pages	2
DOIs	https://doi.org/10.1109/BIBE.2010.55
State	Published - 2010
Event	10th IEEE International Conference on Bioinformatics and Bioengineering, BIBE-2010 - Philadelphia, PA, United States Duration: May 31 2010 → Jun 3 2010

Publication series

Name	10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010

Other

Other	10th IEEE International Conference on Bioinformatics and Bioengineering, BIBE-2010
Country/Territory	United States
City	Philadelphia, PA
Period	5/31/10 → 6/3/10

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ARF
Breast cancer
Multimodal imaging system
Optical spectroscopy

ASJC Scopus subject areas

Biomedical Engineering
Health Informatics

Access to Document

10.1109/BIBE.2010.55

Cite this

Yan, K., Podder, T., Huang, K., Yu, Y., & Liao, L. (2010). A noninvasive multimodal sono-contrast NIR spectroscopy system for breast cancer diagnosis. In 10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010 (pp. 285-286). Article 5521674 (10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010). https://doi.org/10.1109/BIBE.2010.55

A noninvasive multimodal sono-contrast NIR spectroscopy system for breast cancer diagnosis. / Yan, Kaiguo; Podder, Tarun; Huang, Ke et al.
10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010. 2010. p. 285-286 5521674 (10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Yan, K, Podder, T, Huang, K, Yu, Y & Liao, L 2010, A noninvasive multimodal sono-contrast NIR spectroscopy system for breast cancer diagnosis. in 10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010., 5521674, 10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010, pp. 285-286, 10th IEEE International Conference on Bioinformatics and Bioengineering, BIBE-2010, Philadelphia, PA, United States, 5/31/10. https://doi.org/10.1109/BIBE.2010.55

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abstract = "We have developed a multimodal imaging system that combines three modalities, optical spectroscopy, ultrasonography and acoustic radiation force (ARF) for improving diagnosis of breast cancer based on noninvasive interrogation of vasculature. This paper presents a detailed system design. The safety issues regarding the use of laser and ultrasound have also been addressed in this paper. The maximum exposure to skin for laser was controlled within 0.2 W·cm-2 (ANSI Z136.1); exposure from ARF fields were maintained below the FDA diagnostic limit (0.72 W·cm-2). This multimodal system has the potential to improve tumor detection by deploying ARF to produce a measurable difference in the dynamic behavior of the tissue blood supply environment as interrogated by optical spectroscopy, which was demonstrated to be highly diagnostic in a murine tumor model. Pilot clinical study is being carried out.",

keywords = "ARF, Breast cancer, Multimodal imaging system, Optical spectroscopy",

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N2 - We have developed a multimodal imaging system that combines three modalities, optical spectroscopy, ultrasonography and acoustic radiation force (ARF) for improving diagnosis of breast cancer based on noninvasive interrogation of vasculature. This paper presents a detailed system design. The safety issues regarding the use of laser and ultrasound have also been addressed in this paper. The maximum exposure to skin for laser was controlled within 0.2 W·cm-2 (ANSI Z136.1); exposure from ARF fields were maintained below the FDA diagnostic limit (0.72 W·cm-2). This multimodal system has the potential to improve tumor detection by deploying ARF to produce a measurable difference in the dynamic behavior of the tissue blood supply environment as interrogated by optical spectroscopy, which was demonstrated to be highly diagnostic in a murine tumor model. Pilot clinical study is being carried out.

AB - We have developed a multimodal imaging system that combines three modalities, optical spectroscopy, ultrasonography and acoustic radiation force (ARF) for improving diagnosis of breast cancer based on noninvasive interrogation of vasculature. This paper presents a detailed system design. The safety issues regarding the use of laser and ultrasound have also been addressed in this paper. The maximum exposure to skin for laser was controlled within 0.2 W·cm-2 (ANSI Z136.1); exposure from ARF fields were maintained below the FDA diagnostic limit (0.72 W·cm-2). This multimodal system has the potential to improve tumor detection by deploying ARF to produce a measurable difference in the dynamic behavior of the tissue blood supply environment as interrogated by optical spectroscopy, which was demonstrated to be highly diagnostic in a murine tumor model. Pilot clinical study is being carried out.

KW - ARF

KW - Breast cancer

KW - Multimodal imaging system

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A noninvasive multimodal sono-contrast NIR spectroscopy system for breast cancer diagnosis

Abstract

Publication series

Other

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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