A novel fragmentation pathway involving formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry

Lian Zhou; Robert D. Voyksner; Dhiren R. Thakker; Chad E. Stephens; Mariappan Anbazhagan; David W. Boykin; Richard R. Tidwell; James E. Hall

A novel fragmentation pathway involving formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry

Lian Zhou, Robert D. Voyksner, Dhiren R. Thakker, Chad E. Stephens, Mariappan Anbazhagan, David W. Boykin, Richard R. Tidwell, James E. Hall

Research output: Contribution to conference › Paper › peer-review

Abstract

The formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry was investigated. The formation of an odd electron ion from an even electron ion with the loss of a radical was observed in the fragmentation patterns of DB289. The homolytic bond clevage was verified to occur using deuterium exchange and was observed consistently with this class of compounds. The results showed that the proposed homolytic bond cleavage as the lowest-energy reaction pathway for the molecular ion of DB289.

Original language	English (US)
Pages	479-480
Number of pages	2
State	Published - Dec 1 2002
Externally published	Yes
Event	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States Duration: Jun 2 2002 → Jun 6 2002

Other

Other	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
Country/Territory	United States
City	Orlando, FL
Period	6/2/02 → 6/6/02

ASJC Scopus subject areas

Spectroscopy

Cite this

Zhou, L., Voyksner, R. D., Thakker, D. R., Stephens, C. E., Anbazhagan, M., Boykin, D. W., Tidwell, R. R., & Hall, J. E. (2002). A novel fragmentation pathway involving formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry. 479-480. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.

A novel fragmentation pathway involving formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry. / Zhou, Lian; Voyksner, Robert D.; Thakker, Dhiren R. et al.
2002. 479-480 Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.

Research output: Contribution to conference › Paper › peer-review

Zhou, L, Voyksner, RD, Thakker, DR, Stephens, CE, Anbazhagan, M, Boykin, DW, Tidwell, RR & Hall, JE 2002, 'A novel fragmentation pathway involving formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry', Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States, 6/2/02 - 6/6/02 pp. 479-480.

Zhou L, Voyksner RD, Thakker DR, Stephens CE, Anbazhagan M, Boykin DW et al.. A novel fragmentation pathway involving formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry. 2002. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.

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abstract = "The formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry was investigated. The formation of an odd electron ion from an even electron ion with the loss of a radical was observed in the fragmentation patterns of DB289. The homolytic bond clevage was verified to occur using deuterium exchange and was observed consistently with this class of compounds. The results showed that the proposed homolytic bond cleavage as the lowest-energy reaction pathway for the molecular ion of DB289.",

author = "Lian Zhou and Voyksner, {Robert D.} and Thakker, {Dhiren R.} and Stephens, {Chad E.} and Mariappan Anbazhagan and Boykin, {David W.} and Tidwell, {Richard R.} and Hall, {James E.}",

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AU - Zhou, Lian

AU - Voyksner, Robert D.

AU - Thakker, Dhiren R.

AU - Stephens, Chad E.

AU - Anbazhagan, Mariappan

AU - Boykin, David W.

AU - Tidwell, Richard R.

AU - Hall, James E.

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Y1 - 2002/12/1

N2 - The formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry was investigated. The formation of an odd electron ion from an even electron ion with the loss of a radical was observed in the fragmentation patterns of DB289. The homolytic bond clevage was verified to occur using deuterium exchange and was observed consistently with this class of compounds. The results showed that the proposed homolytic bond cleavage as the lowest-energy reaction pathway for the molecular ion of DB289.

AB - The formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry was investigated. The formation of an odd electron ion from an even electron ion with the loss of a radical was observed in the fragmentation patterns of DB289. The homolytic bond clevage was verified to occur using deuterium exchange and was observed consistently with this class of compounds. The results showed that the proposed homolytic bond cleavage as the lowest-energy reaction pathway for the molecular ion of DB289.

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A novel fragmentation pathway involving formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry

Abstract

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ASJC Scopus subject areas

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