A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans

Jennifer C. Naylor, Trygve R. Dolber, Jennifer L. Strauss, Jason D. Kilts, Timothy J. Strauman, Daniel W. Bradford, Steven T. Szabo, Nagy A. Youssef, Kathryn M. Connor, Jonathan R.T. Davidson, Christine E. Marx

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk for suicidality, depression, and functional impairment. We thus conducted a small (N=12) pilot randomized controlled trial (RCT) with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) era veterans. Hospital Anxiety and Depression Scale (HADS) scores improved by 30.4% in the paroxetine group. Paroxetine may have promise for subthreshold PTSD.

Original languageEnglish (US)
Pages (from-to)318-320
Number of pages3
JournalPsychiatry Research
Volume206
Issue number2-3
DOIs
StatePublished - Apr 30 2013
Externally publishedYes

Keywords

  • PTSD
  • Paroxetine
  • Subthreshold

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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