A Postulate on the Brain's Basic Wiring Logic

Joe Z. Tsien

Research output: Contribution to journalShort surveypeer-review

20 Scopus citations


How should evolution and development build the brain to be capable of flexible and generative cognition? I wish to put forth a 'power-of-two'-based wiring logic that provides the basic computational principle in organizing the microarchitecture of cell assemblies that would readily enable knowledge and adaptive behaviors to emerge upon learning.

Original languageEnglish (US)
Pages (from-to)669-671
Number of pages3
JournalTrends in Neurosciences
Issue number11
StatePublished - Nov 2015


  • Artificial intelligence
  • Cell assembly
  • Cognitive computing
  • Development
  • Evolution
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)


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