TY - JOUR
T1 - A single bout of maximal exercise improves lung function in patients with cystic fibrosis
AU - Tucker, Matthew A.
AU - Crandall, Reva
AU - Seigler, Nichole
AU - Rodriguez-Miguelez, Paula
AU - McKie, Kathleen T.
AU - Forseen, Caralee
AU - Thomas, Jeffrey
AU - Harris, Ryan A.
N1 - Funding Information:
This study was supported in part by a Vertex Pharmaceuticals IIS Grant and NIH/NIDDK R21DK100783 (RAH).
Publisher Copyright:
© 2017 European Cystic Fibrosis Society
PY - 2017/11
Y1 - 2017/11
N2 - Background Responses to a single bout of exercise may provide critical information for maximizing improvements in pulmonary function following exercise training in cystic fibrosis (CF). We sought to determine if acute maximal exercise improves pulmonary function in patients with CF. Methods Thirty-three patients with CF completed a comprehensive assessment of pulmonary function to determine forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and lung clearance index (LCI) prior to and immediately following maximal aerobic exercise on a cycle ergometer. Results Following exercise, FVC (∆ 0.08 ± 0.14 L) and FEV1 (∆ 0.06 ± 0.15 L) increased, while LCI decreased (∆-0.71 ± 0.93) (all p < 0.05). Changes in FEV1 (%predicted) were associated with peak work (r = 0.40, p = 0.02) and peak pulmonary ventilation (r = 0.45, p = 0.01). Conclusions A single bout of maximal exercise acutely improves pulmonary function in patients with CF and improvements may be related to peak work and peak pulmonary ventilation.
AB - Background Responses to a single bout of exercise may provide critical information for maximizing improvements in pulmonary function following exercise training in cystic fibrosis (CF). We sought to determine if acute maximal exercise improves pulmonary function in patients with CF. Methods Thirty-three patients with CF completed a comprehensive assessment of pulmonary function to determine forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and lung clearance index (LCI) prior to and immediately following maximal aerobic exercise on a cycle ergometer. Results Following exercise, FVC (∆ 0.08 ± 0.14 L) and FEV1 (∆ 0.06 ± 0.15 L) increased, while LCI decreased (∆-0.71 ± 0.93) (all p < 0.05). Changes in FEV1 (%predicted) were associated with peak work (r = 0.40, p = 0.02) and peak pulmonary ventilation (r = 0.45, p = 0.01). Conclusions A single bout of maximal exercise acutely improves pulmonary function in patients with CF and improvements may be related to peak work and peak pulmonary ventilation.
KW - Exercise capacity
KW - Impulse oscillometry
KW - Multi-breath washout
KW - Spirometry
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U2 - 10.1016/j.jcf.2017.05.011
DO - 10.1016/j.jcf.2017.05.011
M3 - Article
C2 - 28651845
AN - SCOPUS:85021227760
SN - 1569-1993
VL - 16
SP - 752
EP - 758
JO - Journal of Cystic Fibrosis
JF - Journal of Cystic Fibrosis
IS - 6
ER -