TY - JOUR
T1 - A three-dimensional morphometric study of craniofacial shape in schizophrenia
AU - Buckley, Peter F.
AU - Dean, David
AU - Bookstein, Fred L.
AU - Han, Seungho
AU - Yerukhimovich, Michael
AU - Min, Kyoung June
AU - Singer, Beth
PY - 2005/3
Y1 - 2005/3
N2 - Background: Subtle dysmorphogenesis of the craniofacial region constitutes important corroborating evidence of the neurodevelopmental origins of schizophrenia. Advances in facial visualization now allow for three-dimensional anthropometric evaluations of potentially greater discriminatory power in examining the complex geometric relationships of facial topography. Method: Sixty-five anthropometrically derived landmarks were identified from three-dimensional facial images collected from 14 patients with schizophrenia and 11 comparison subjects, imaged with a high-resolution, portable laser scanner. Results: Using the Procrustes morphometric approach for shape analysis, the difference in mean shapes was highly significant, with patients exhibiting superoinferior elongation of the face. Conclusions: The topography of craniofacial anomalies in schizophrenia is not random and points to midline deformation.
AB - Background: Subtle dysmorphogenesis of the craniofacial region constitutes important corroborating evidence of the neurodevelopmental origins of schizophrenia. Advances in facial visualization now allow for three-dimensional anthropometric evaluations of potentially greater discriminatory power in examining the complex geometric relationships of facial topography. Method: Sixty-five anthropometrically derived landmarks were identified from three-dimensional facial images collected from 14 patients with schizophrenia and 11 comparison subjects, imaged with a high-resolution, portable laser scanner. Results: Using the Procrustes morphometric approach for shape analysis, the difference in mean shapes was highly significant, with patients exhibiting superoinferior elongation of the face. Conclusions: The topography of craniofacial anomalies in schizophrenia is not random and points to midline deformation.
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U2 - 10.1176/appi.ajp.162.3.606
DO - 10.1176/appi.ajp.162.3.606
M3 - Article
C2 - 15741481
AN - SCOPUS:14844332719
SN - 0002-953X
VL - 162
SP - 606
EP - 608
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 3
ER -
