A variable embryotoxic response to lead in different strains of hamsters

Thomas F. Gale

doi:10.1016/0013-9351(78)90036-1

A variable embryotoxic response to lead in different strains of hamsters

Thomas F. Gale

Cellular Biology and Anatomy

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Lead nitrate was administered intravenously at 50 mg/kg to five inbred strains (MHA, LSH, LHC, CB, AND P)4) and the non-inbred LVG strain of pregnant hamsters early on the 8th gestation day. All fetuses from treated and control hamsters were collected on the 15th gestation day and examined for the frequency and kinds of external, internal, and skeletal abnormalities. The major embryotoxic effects included resorptions, tail bud abnormalities, hydrocephalus, and skeletal defects. It is concluded that the LSH, LHC, LVG, and PD4 strains are susceptible while the MHA and CB strains are relatively resistant to the lead exposure.

Original language	English (US)
Pages (from-to)	325-333
Number of pages	9
Journal	Environmental Research
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/0013-9351(78)90036-1
State	Published - Dec 1978

ASJC Scopus subject areas

Biochemistry
General Environmental Science

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10.1016/0013-9351(78)90036-1

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title = "A variable embryotoxic response to lead in different strains of hamsters",

abstract = "Lead nitrate was administered intravenously at 50 mg/kg to five inbred strains (MHA, LSH, LHC, CB, AND P)4) and the non-inbred LVG strain of pregnant hamsters early on the 8th gestation day. All fetuses from treated and control hamsters were collected on the 15th gestation day and examined for the frequency and kinds of external, internal, and skeletal abnormalities. The major embryotoxic effects included resorptions, tail bud abnormalities, hydrocephalus, and skeletal defects. It is concluded that the LSH, LHC, LVG, and PD4 strains are susceptible while the MHA and CB strains are relatively resistant to the lead exposure.",

author = "Gale, \{Thomas F.\}",

note = "Funding Information: This study was supported in part by NIH Grant RR05365 and in part by a grant from the Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Hanover, New Hampshire, under NIH, NC1 Contract NOI-CN-55199. The technical assistance of Mrs. Martha L. Hill. Miss Kerry Bruker, and Ms. Janice Reese is greatly appreciated.",

year = "1978",

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doi = "10.1016/0013-9351(78)90036-1",

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T1 - A variable embryotoxic response to lead in different strains of hamsters

AU - Gale, Thomas F.

N1 - Funding Information: This study was supported in part by NIH Grant RR05365 and in part by a grant from the Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Hanover, New Hampshire, under NIH, NC1 Contract NOI-CN-55199. The technical assistance of Mrs. Martha L. Hill. Miss Kerry Bruker, and Ms. Janice Reese is greatly appreciated.

PY - 1978/12

Y1 - 1978/12

N2 - Lead nitrate was administered intravenously at 50 mg/kg to five inbred strains (MHA, LSH, LHC, CB, AND P)4) and the non-inbred LVG strain of pregnant hamsters early on the 8th gestation day. All fetuses from treated and control hamsters were collected on the 15th gestation day and examined for the frequency and kinds of external, internal, and skeletal abnormalities. The major embryotoxic effects included resorptions, tail bud abnormalities, hydrocephalus, and skeletal defects. It is concluded that the LSH, LHC, LVG, and PD4 strains are susceptible while the MHA and CB strains are relatively resistant to the lead exposure.

AB - Lead nitrate was administered intravenously at 50 mg/kg to five inbred strains (MHA, LSH, LHC, CB, AND P)4) and the non-inbred LVG strain of pregnant hamsters early on the 8th gestation day. All fetuses from treated and control hamsters were collected on the 15th gestation day and examined for the frequency and kinds of external, internal, and skeletal abnormalities. The major embryotoxic effects included resorptions, tail bud abnormalities, hydrocephalus, and skeletal defects. It is concluded that the LSH, LHC, LVG, and PD4 strains are susceptible while the MHA and CB strains are relatively resistant to the lead exposure.

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DO - 10.1016/0013-9351(78)90036-1

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A variable embryotoxic response to lead in different strains of hamsters

Abstract

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