Aberrant cytokine gene expression in the hippocampus in murine systemic lupus erythematosus

Michiyo Tomita; Brita J. Holman; Thomas J. Santoro

doi:10.1016/S0304-3940(01)01679-2

Aberrant cytokine gene expression in the hippocampus in murine systemic lupus erythematosus

Michiyo Tomita, Brita J. Holman, Thomas J. Santoro

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Cytokines are important mediators of immune regulation and have been implicated in the pathogenesis of the neurological disturbances, which occur in up to sixty percent of patients with systemic lupus erythematosus (SLE). SLE is an autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, including native DNA. Cytokines are thought to drive autoantibody production in lupus. Certain of the derangements in memory and learning described in human and experimental SLE map to the hippocampus. The current study examines the expression of cytokine genes in the hippocampus in lupus, using MRL-lpr/lpr mice as the experimental model. These mice spontaneously develop a SLE-like illness accompanied by disturbances in spatial learning. Our results suggest a potential role for proinflammatory cytokines in the cognitive aberrations observed in lupus.

Original language	English (US)
Pages (from-to)	129-132
Number of pages	4
Journal	Neuroscience Letters
Volume	302
Issue number	2-3
DOIs	https://doi.org/10.1016/S0304-3940(01)01679-2
State	Published - Apr 20 2001
Externally published	Yes

Keywords

Cytokines
Gene expression
Hippocampus
MRL-lpr/lpr mice
Systemic lupus erythematosus

ASJC Scopus subject areas

General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3940(01)01679-2

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title = "Aberrant cytokine gene expression in the hippocampus in murine systemic lupus erythematosus",

abstract = "Cytokines are important mediators of immune regulation and have been implicated in the pathogenesis of the neurological disturbances, which occur in up to sixty percent of patients with systemic lupus erythematosus (SLE). SLE is an autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, including native DNA. Cytokines are thought to drive autoantibody production in lupus. Certain of the derangements in memory and learning described in human and experimental SLE map to the hippocampus. The current study examines the expression of cytokine genes in the hippocampus in lupus, using MRL-lpr/lpr mice as the experimental model. These mice spontaneously develop a SLE-like illness accompanied by disturbances in spatial learning. Our results suggest a potential role for proinflammatory cytokines in the cognitive aberrations observed in lupus.",

keywords = "Cytokines, Gene expression, Hippocampus, MRL-lpr/lpr mice, Systemic lupus erythematosus",

author = "Michiyo Tomita and Holman, {Brita J.} and Santoro, {Thomas J.}",

note = "Funding Information: This work was supported in part by a grant from the Northwest Ohio Chapter of the Lupus Foundation of America.",

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doi = "10.1016/S0304-3940(01)01679-2",

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T1 - Aberrant cytokine gene expression in the hippocampus in murine systemic lupus erythematosus

AU - Tomita, Michiyo

AU - Holman, Brita J.

AU - Santoro, Thomas J.

N1 - Funding Information: This work was supported in part by a grant from the Northwest Ohio Chapter of the Lupus Foundation of America.

PY - 2001/4/20

Y1 - 2001/4/20

N2 - Cytokines are important mediators of immune regulation and have been implicated in the pathogenesis of the neurological disturbances, which occur in up to sixty percent of patients with systemic lupus erythematosus (SLE). SLE is an autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, including native DNA. Cytokines are thought to drive autoantibody production in lupus. Certain of the derangements in memory and learning described in human and experimental SLE map to the hippocampus. The current study examines the expression of cytokine genes in the hippocampus in lupus, using MRL-lpr/lpr mice as the experimental model. These mice spontaneously develop a SLE-like illness accompanied by disturbances in spatial learning. Our results suggest a potential role for proinflammatory cytokines in the cognitive aberrations observed in lupus.

AB - Cytokines are important mediators of immune regulation and have been implicated in the pathogenesis of the neurological disturbances, which occur in up to sixty percent of patients with systemic lupus erythematosus (SLE). SLE is an autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, including native DNA. Cytokines are thought to drive autoantibody production in lupus. Certain of the derangements in memory and learning described in human and experimental SLE map to the hippocampus. The current study examines the expression of cytokine genes in the hippocampus in lupus, using MRL-lpr/lpr mice as the experimental model. These mice spontaneously develop a SLE-like illness accompanied by disturbances in spatial learning. Our results suggest a potential role for proinflammatory cytokines in the cognitive aberrations observed in lupus.

KW - Cytokines

KW - Gene expression

KW - Hippocampus

KW - MRL-lpr/lpr mice

KW - Systemic lupus erythematosus

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ER -

Aberrant cytokine gene expression in the hippocampus in murine systemic lupus erythematosus

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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