Aberrant expression of the tumour suppressor gene p53 is very frequent in Wilms' tumours

Nicholas R. Lemoine; Christine M. Hughes; John K. Cowell

doi:10.1002/path.1711680213

Aberrant expression of the tumour suppressor gene p53 is very frequent in Wilms' tumours

Nicholas R. Lemoine, Christine M. Hughes, John K. Cowell

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A series of 34 Wilms' tumours have been analysed for abnormal expression of the tumour suppressor gene p53 using frozen section immunohistochemistry. All tumours showed immunoreactivity with at least one of the specific antibodies used (monoclonal antibody PAb240, polyclonal antibodies CM 1 and JG8). Abnormalities of p53 expression are very frequent in this type of childhood tumour.

Original language	English (US)
Pages (from-to)	237-242
Number of pages	6
Journal	The Journal of Pathology
Volume	168
Issue number	2
DOIs	https://doi.org/10.1002/path.1711680213
State	Published - Oct 1992
Externally published	Yes

Keywords

Tumour suppressor gene
Wilms' tumour
immunohistochemistry
p53

ASJC Scopus subject areas

Pathology and Forensic Medicine

Access to Document

10.1002/path.1711680213

Cite this

@article{103ceea2baff426aafebedff6c703a56,

title = "Aberrant expression of the tumour suppressor gene p53 is very frequent in Wilms' tumours",

abstract = "A series of 34 Wilms' tumours have been analysed for abnormal expression of the tumour suppressor gene p53 using frozen section immunohistochemistry. All tumours showed immunoreactivity with at least one of the specific antibodies used (monoclonal antibody PAb240, polyclonal antibodies CM 1 and JG8). Abnormalities of p53 expression are very frequent in this type of childhood tumour.",

keywords = "Tumour suppressor gene, Wilms' tumour, immunohistochemistry, p53",

author = "Lemoine, {Nicholas R.} and Hughes, {Christine M.} and Cowell, {John K.}",

year = "1992",

month = oct,

doi = "10.1002/path.1711680213",

language = "English (US)",

volume = "168",

pages = "237--242",

journal = "The Journal of Pathology",

issn = "0022-3417",

publisher = "John Wiley and Sons Ltd",

number = "2",

}

TY - JOUR

T1 - Aberrant expression of the tumour suppressor gene p53 is very frequent in Wilms' tumours

AU - Lemoine, Nicholas R.

AU - Hughes, Christine M.

AU - Cowell, John K.

PY - 1992/10

Y1 - 1992/10

N2 - A series of 34 Wilms' tumours have been analysed for abnormal expression of the tumour suppressor gene p53 using frozen section immunohistochemistry. All tumours showed immunoreactivity with at least one of the specific antibodies used (monoclonal antibody PAb240, polyclonal antibodies CM 1 and JG8). Abnormalities of p53 expression are very frequent in this type of childhood tumour.

AB - A series of 34 Wilms' tumours have been analysed for abnormal expression of the tumour suppressor gene p53 using frozen section immunohistochemistry. All tumours showed immunoreactivity with at least one of the specific antibodies used (monoclonal antibody PAb240, polyclonal antibodies CM 1 and JG8). Abnormalities of p53 expression are very frequent in this type of childhood tumour.

KW - Tumour suppressor gene

KW - Wilms' tumour

KW - immunohistochemistry

KW - p53

UR - http://www.scopus.com/inward/record.url?scp=0026457082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026457082&partnerID=8YFLogxK

U2 - 10.1002/path.1711680213

DO - 10.1002/path.1711680213

M3 - Article

C2 - 1334142

AN - SCOPUS:0026457082

SN - 0022-3417

VL - 168

SP - 237

EP - 242

JO - The Journal of Pathology

JF - The Journal of Pathology

IS - 2

ER -

Aberrant expression of the tumour suppressor gene p53 is very frequent in Wilms' tumours

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this