TY - JOUR
T1 - Accelerated Biologic Aging, Chronic Stress, and Risk for Sepsis and Organ Failure Following Trauma
AU - NeSmith, Elizabeth G.
AU - Medeiros, Regina S.
AU - Holsten, Steven B.
AU - Zhu, Haidong
AU - Looney, Stephen W.
AU - Dong, Yanbin
N1 - Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Chronic stress and accelerated aging have been shown to impact the inflammatory response and related outcomes like sepsis and organ failure, but data are lacking in the trauma literature. The purpose of this study was to investigate potential relationships between pretrauma stress and posttrauma outcomes. The hypothesis was that pretrauma chronic stress accelerates aging, which increases susceptibility to posttrauma sepsis and organ failure. In this prospective, correlational study, chronic stress and accelerated biologic aging were compared to the occurrence of systemic inflammatory response syndrome, sepsis, and organ failure in trauma patients aged 18-44 years. Results supported the hypothesis with significant overall associations between susceptibility to sepsis and accelerated biologic aging (n = 142). There were also significant negative associations between mean cytokine levels and chronic stress. The strongest association was found between mean interleukin-1β (IL-1β) and human telomerase reverse transcriptase (hTERT), r(101) = -0.28), p =.004. Significant negative associations were found between mean cytokine levels, IL-12p70, r(108) = -0.20, p =.034; and tumor necrosis factor- (TNF-), r(108) = -0.20, p =.033, and positive life events via the behavioral measure of chronic stress. Results may help identify individuals at increased risk for poor outcomes of trauma and inform interventions that may reduce the risk for sepsis and organ failure.
AB - Chronic stress and accelerated aging have been shown to impact the inflammatory response and related outcomes like sepsis and organ failure, but data are lacking in the trauma literature. The purpose of this study was to investigate potential relationships between pretrauma stress and posttrauma outcomes. The hypothesis was that pretrauma chronic stress accelerates aging, which increases susceptibility to posttrauma sepsis and organ failure. In this prospective, correlational study, chronic stress and accelerated biologic aging were compared to the occurrence of systemic inflammatory response syndrome, sepsis, and organ failure in trauma patients aged 18-44 years. Results supported the hypothesis with significant overall associations between susceptibility to sepsis and accelerated biologic aging (n = 142). There were also significant negative associations between mean cytokine levels and chronic stress. The strongest association was found between mean interleukin-1β (IL-1β) and human telomerase reverse transcriptase (hTERT), r(101) = -0.28), p =.004. Significant negative associations were found between mean cytokine levels, IL-12p70, r(108) = -0.20, p =.034; and tumor necrosis factor- (TNF-), r(108) = -0.20, p =.033, and positive life events via the behavioral measure of chronic stress. Results may help identify individuals at increased risk for poor outcomes of trauma and inform interventions that may reduce the risk for sepsis and organ failure.
KW - Aging
KW - Inflammation
KW - Sepsis
KW - Stress
KW - Trauma
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U2 - 10.1097/JTN.0000000000000501
DO - 10.1097/JTN.0000000000000501
M3 - Article
C2 - 32371728
AN - SCOPUS:85084329101
SN - 1078-7496
VL - 27
SP - 131
EP - 140
JO - Journal of Trauma Nursing
JF - Journal of Trauma Nursing
IS - 3
ER -