ACTH protects against glucocorticoid-induced osteonecrosis of bone

Mone Zaidi; Li Sun; Lisa J. Robinson; Irina L. Tourkova; Li Liu; Yujuan Wang; Ling Ling Zhu; Xuan Liu; Jianhua Li; Yuanzhen Peng; Guozhe Yang; Xing Ming Shi; Alice Levine; Jameel Iqbal; Beatrice B. Yaroslavskiy; Carlos M Isales; Harry C. Blair

doi:10.1073/pnas.0912176107

ACTH protects against glucocorticoid-induced osteonecrosis of bone

Mone Zaidi, Li Sun, Lisa J. Robinson, Irina L. Tourkova, Li Liu, Yujuan Wang, Ling Ling Zhu, Xuan Liu, Jianhua Li, Yuanzhen Peng, Guozhe Yang, Xing Ming Shi, Alice Levine, Jameel Iqbal, Beatrice B. Yaroslavskiy, Carlos M Isales, Harry C. Blair

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130 Scopus citations

Abstract

We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the fine vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy.

Original language	English (US)
Pages (from-to)	8782-8787
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	107
Issue number	19
DOIs	https://doi.org/10.1073/pnas.0912176107
State	Published - May 11 2010

Keywords

Osteoblast
Osteoclast
Osteoporosis

ASJC Scopus subject areas

General

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Zaidi, M., Sun, L., Robinson, L. J., Tourkova, I. L., Liu, L., Wang, Y., Zhu, L. L., Liu, X., Li, J., Peng, Y., Yang, G., Shi, X. M., Levine, A., Iqbal, J., Yaroslavskiy, B. B., Isales, C. M., & Blair, H. C. (2010). ACTH protects against glucocorticoid-induced osteonecrosis of bone. Proceedings of the National Academy of Sciences of the United States of America, 107(19), 8782-8787. https://doi.org/10.1073/pnas.0912176107

Zaidi, M, Sun, L, Robinson, LJ, Tourkova, IL, Liu, L, Wang, Y, Zhu, LL, Liu, X, Li, J, Peng, Y, Yang, G, Shi, XM, Levine, A, Iqbal, J, Yaroslavskiy, BB, Isales, CM & Blair, HC 2010, 'ACTH protects against glucocorticoid-induced osteonecrosis of bone', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 19, pp. 8782-8787. https://doi.org/10.1073/pnas.0912176107

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abstract = "We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the fine vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy.",

keywords = "Osteoblast, Osteoclast, Osteoporosis",

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doi = "10.1073/pnas.0912176107",

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T1 - ACTH protects against glucocorticoid-induced osteonecrosis of bone

AU - Zaidi, Mone

AU - Sun, Li

AU - Robinson, Lisa J.

AU - Tourkova, Irina L.

AU - Liu, Li

AU - Wang, Yujuan

AU - Zhu, Ling Ling

AU - Liu, Xuan

AU - Li, Jianhua

AU - Peng, Yuanzhen

AU - Yang, Guozhe

AU - Shi, Xing Ming

AU - Levine, Alice

AU - Iqbal, Jameel

AU - Yaroslavskiy, Beatrice B.

AU - Isales, Carlos M

AU - Blair, Harry C.

PY - 2010/5/11

Y1 - 2010/5/11

N2 - We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the fine vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy.

AB - We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the fine vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy.

KW - Osteoblast

KW - Osteoclast

KW - Osteoporosis

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ACTH protects against glucocorticoid-induced osteonecrosis of bone

Abstract

Keywords

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