Action Spectra for Ultraviolet Light-Induced Transformation of Human Cells to Anchorage-Independent Growth

Betsy M. Sutherland; Rowena P. Oliver; Neva C. Delihas; John Clark Sutherland

Action Spectra for Ultraviolet Light-Induced Transformation of Human Cells to Anchorage-Independent Growth

Betsy M. Sutherland, Rowena P. Oliver, Neva C. Delihas, John Clark Sutherland

Research output: Contribution to journal › Article › peer-review

Abstract

We have determined action spectra for transformation of human embryonic skin and muscle fibroblasts to anchorage-independent growth. Tests under our experimental conditions indicate that reciprocity holds for photon rate and exposure time and that all the dose-effect curves in the wavelength range of 248 to 297 nm are similar. These data can be used to construct action spectra with a maximum at about 265 nm, which do not implicate moieties other than nucleic acids as absorbers in the transformation process.

Original language	English (US)
Pages (from-to)	2211-2214
Number of pages	4
Journal	Cancer Research
Volume	41
Issue number	6
State	Published - Jun 1 1981
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Action Spectra for Ultraviolet Light-Induced Transformation of Human Cells to Anchorage-Independent Growth",

abstract = "We have determined action spectra for transformation of human embryonic skin and muscle fibroblasts to anchorage-independent growth. Tests under our experimental conditions indicate that reciprocity holds for photon rate and exposure time and that all the dose-effect curves in the wavelength range of 248 to 297 nm are similar. These data can be used to construct action spectra with a maximum at about 265 nm, which do not implicate moieties other than nucleic acids as absorbers in the transformation process.",

author = "Sutherland, {Betsy M.} and Oliver, {Rowena P.} and Delihas, {Neva C.} and Sutherland, {John Clark}",

year = "1981",

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AU - Sutherland, Betsy M.

AU - Oliver, Rowena P.

AU - Delihas, Neva C.

AU - Sutherland, John Clark

PY - 1981/6/1

Y1 - 1981/6/1

N2 - We have determined action spectra for transformation of human embryonic skin and muscle fibroblasts to anchorage-independent growth. Tests under our experimental conditions indicate that reciprocity holds for photon rate and exposure time and that all the dose-effect curves in the wavelength range of 248 to 297 nm are similar. These data can be used to construct action spectra with a maximum at about 265 nm, which do not implicate moieties other than nucleic acids as absorbers in the transformation process.

AB - We have determined action spectra for transformation of human embryonic skin and muscle fibroblasts to anchorage-independent growth. Tests under our experimental conditions indicate that reciprocity holds for photon rate and exposure time and that all the dose-effect curves in the wavelength range of 248 to 297 nm are similar. These data can be used to construct action spectra with a maximum at about 265 nm, which do not implicate moieties other than nucleic acids as absorbers in the transformation process.

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AN - SCOPUS:0019460037

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Action Spectra for Ultraviolet Light-Induced Transformation of Human Cells to Anchorage-Independent Growth

Abstract

ASJC Scopus subject areas

UN SDGs

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