Acute kidney injury: Novel biomarkers and potential utility for patient care in urology

Anil A. Thomas; Sevag Demirjian; Brian R. Lane; Matthew N. Simmons; David A. Goldfarb; Vairavan S. Subramanian; Steven C. Campbell

doi:10.1016/j.urology.2010.05.004

Acute kidney injury: Novel biomarkers and potential utility for patient care in urology

Anil A. Thomas, Sevag Demirjian, Brian R. Lane, Matthew N. Simmons, David A. Goldfarb, Vairavan S. Subramanian, Steven C. Campbell

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Urologists are integrally involved in the management of acute kidney injury (AKI), which is common after renal surgery or secondary to postrenal (obstructive) etiologies. The measurement of serum creatinine is a suboptimal indicator of AKI because it lags behind acute changes in renal function. Recent advances indicate that serum/urine biomarkers will prove useful for early detection of AKI, analogous to the use of cardiac enzymes for acute myocardial infarction. These serum/urine markers may guide future therapy, facilitate research efforts to reduce the severity of AKI, such as after partial nephrectomy, and allow for more accurate prognostication for patients with AKI.

Original language	English (US)
Pages (from-to)	5-11
Number of pages	7
Journal	Urology
Volume	77
Issue number	1
DOIs	https://doi.org/10.1016/j.urology.2010.05.004
State	Published - Jan 2011
Externally published	Yes

ASJC Scopus subject areas

Urology

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abstract = "Urologists are integrally involved in the management of acute kidney injury (AKI), which is common after renal surgery or secondary to postrenal (obstructive) etiologies. The measurement of serum creatinine is a suboptimal indicator of AKI because it lags behind acute changes in renal function. Recent advances indicate that serum/urine biomarkers will prove useful for early detection of AKI, analogous to the use of cardiac enzymes for acute myocardial infarction. These serum/urine markers may guide future therapy, facilitate research efforts to reduce the severity of AKI, such as after partial nephrectomy, and allow for more accurate prognostication for patients with AKI.",

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AU - Lane, Brian R.

AU - Simmons, Matthew N.

AU - Goldfarb, David A.

AU - Subramanian, Vairavan S.

AU - Campbell, Steven C.

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AB - Urologists are integrally involved in the management of acute kidney injury (AKI), which is common after renal surgery or secondary to postrenal (obstructive) etiologies. The measurement of serum creatinine is a suboptimal indicator of AKI because it lags behind acute changes in renal function. Recent advances indicate that serum/urine biomarkers will prove useful for early detection of AKI, analogous to the use of cardiac enzymes for acute myocardial infarction. These serum/urine markers may guide future therapy, facilitate research efforts to reduce the severity of AKI, such as after partial nephrectomy, and allow for more accurate prognostication for patients with AKI.

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Acute kidney injury: Novel biomarkers and potential utility for patient care in urology

Abstract

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