Acute myeloid leukemia with MYC rearrangement and JAK2 V617F mutation

Maro Ohanian, Carlos Bueso-Ramos, Chi Young Ok, Pei Lin, Keyur Patel, Mona Lisa Alattar, Joseph D. Khoury, Uri Rozovski, Zeev Estrov, Yang O. Huh, Jorge Cortes, Lynne V. Abruzzo

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Little is known about MYC dysregulation in myeloid malignancies, and the authors were unable to find published studies that evaluated MYC protein expression in primary cases of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Herein, we describe the clinical, morphologic, immunophenotypic, cytogenetic, and molecular genetic findings in two MDS/AML cases that contained both MYC rearrangement and the JAK2 V617F mutation. We also demonstrate MYC protein expression by immunohistochemistry in both patients.

Original languageEnglish (US)
Pages (from-to)571-574
Number of pages4
JournalCancer Genetics
Issue number11
StatePublished - Nov 2015
Externally publishedYes


  • Acute myeloid leukemia
  • Blastic plasmacytoid dendritic cell neoplasm
  • JAK2 V617F mutation
  • MYC

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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