TY - JOUR
T1 - Adaptive immunity-driven inflammation and cardiovascular disease
AU - Ilatovskaya, Daria V.
AU - Halade, Ganesh V.
AU - DeLeon-Pennell, Kristine Y.
N1 - Funding Information:
This work was supported by the National Institutes of Health (NIH) Grant R00-DK-105160 (to D. V. Ilatovskaya); NIH Grants HL-132989 and HL-144788 and University of Alabama at Birmingham Pittman Scholar Award (to G. V. Halade); and NIH Grant U54-DA-016511 and the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development Award IK2BX003922 (to K. Y. DeLeon-Pennell). This work was also financially supported, in part, by the 2019 S&R Foundation Ryuji Ueno Award (to K. Y. DeLeon-Pennell) by the American Physiological Society.
Publisher Copyright:
© 2019 American Physiological Society. All rights reserved.
PY - 2019
Y1 - 2019
N2 - The adaptive immune response has recently emerged as an important factor in a wide variety of cardiovascular disorders including atherosclerosis, hypertension, cardiac remodeling, and heart failure; however, its role is not fully understood. Since an assortment of innate responsive cells, e.g., neutrophils and monocytes/macrophages, coordinate with adaptive immunity, e.g., T cells, dendritic cells, and B cells, the temporal response and descriptions pertinent to the cellular phenotype and inflammation processes, in general, need additional investigation, clarification, and consensus particularly in cardiovascular disease. This Perspectives article reviews the contributions of 15 articles (including 7 reviews) published in the American Journal of Physiology-Heart and Circulatory Physiology in response to the Call for Papers: Adaptive Immunity in Cardiovascular Disease. Here, we summarize the crucial reported findings at the cardiac, vascular, immune, and molecular levels and discuss the translational feasibility and benefits of future prospective research into the adaptive immune response. Readers are encouraged to evaluate the data and learn from this collection of novel studies.
AB - The adaptive immune response has recently emerged as an important factor in a wide variety of cardiovascular disorders including atherosclerosis, hypertension, cardiac remodeling, and heart failure; however, its role is not fully understood. Since an assortment of innate responsive cells, e.g., neutrophils and monocytes/macrophages, coordinate with adaptive immunity, e.g., T cells, dendritic cells, and B cells, the temporal response and descriptions pertinent to the cellular phenotype and inflammation processes, in general, need additional investigation, clarification, and consensus particularly in cardiovascular disease. This Perspectives article reviews the contributions of 15 articles (including 7 reviews) published in the American Journal of Physiology-Heart and Circulatory Physiology in response to the Call for Papers: Adaptive Immunity in Cardiovascular Disease. Here, we summarize the crucial reported findings at the cardiac, vascular, immune, and molecular levels and discuss the translational feasibility and benefits of future prospective research into the adaptive immune response. Readers are encouraged to evaluate the data and learn from this collection of novel studies.
KW - Adaptive immunity
KW - Atherosclerosis
KW - Eosinphilia
KW - Hypertension
KW - Myocardial infarction
UR - http://www.scopus.com/inward/record.url?scp=85075813367&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075813367&partnerID=8YFLogxK
U2 - 10.1152/ajpheart.00642.2019
DO - 10.1152/ajpheart.00642.2019
M3 - Article
C2 - 31702971
AN - SCOPUS:85075813367
SN - 0363-6135
VL - 317
SP - H1254-H1257
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
IS - 6
ER -
