Abstract
Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its own pattern of expression in the digestive system and differential regulation of function by Ca2+ and other intracellular signals. In addition to the transmembrane isoforms, one AC is soluble and exhibits distinct regulation. In this review, the basic structure, regulation and physiological roles of ACs in the digestive system are discussed.
Original language | English (US) |
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Pages (from-to) | 1173-1181 |
Number of pages | 9 |
Journal | Cellular Signalling |
Volume | 26 |
Issue number | 6 |
DOIs | |
State | Published - 2014 |
Keywords
- Adenylyl cyclase
- Exocrine pancreas
- Intestine
- Liver
- Salivary gland
- Stomach
ASJC Scopus subject areas
- Cell Biology