Adenylyl cyclases in the digestive system

Maria Eugenia Sabbatini, Fred Gorelick, Shannon Glaser

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its own pattern of expression in the digestive system and differential regulation of function by Ca2+ and other intracellular signals. In addition to the transmembrane isoforms, one AC is soluble and exhibits distinct regulation. In this review, the basic structure, regulation and physiological roles of ACs in the digestive system are discussed.

Original languageEnglish (US)
Pages (from-to)1173-1181
Number of pages9
JournalCellular Signalling
Issue number6
StatePublished - 2014


  • Adenylyl cyclase
  • Exocrine pancreas
  • Intestine
  • Liver
  • Salivary gland
  • Stomach

ASJC Scopus subject areas

  • Cell Biology


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