TY - JOUR
T1 - Adjunctive azithromycin in the treatment of aggressive periodontitis
T2 - Microbiological findings of a 12-month randomized clinical trial
AU - Haas, Alex Nogueira
AU - Silva-Boghossian, Carina Mac Iel
AU - Colombo, Ana Paula
AU - Susin, Cristiano
AU - Albandar, Jasim M.
AU - Oppermann, Rui Vicente
AU - Rösing, Cassiano Kuchenbecker
N1 - Funding Information:
This study was funded, in part, by the Foundation for Post-Graduate Education (CAPES), Ministry of Education, Brasilia, DF, Brazil (grant number 1614/99-1 ).
PY - 2012/7
Y1 - 2012/7
N2 - Objectives: To compare the subgingival microbiological outcomes of azithromycin or placebo as adjuncts to scaling and root planing (SRP) in the treatment of aggressive periodontitis (AgP), and to secondarily evaluate the microbiological effect of supragingival scaling in AgP patients. Methods: Twenty-four AgP subjects 13-26 years of age received a 15-day programme of supragingival scaling (SC) and were then randomly assigned to SRP with systemic azithromycin or placebo. Subgingival samples were taken with sterile paper points at baseline, 15 days after SC, and at 3, 6 and 12 months following SRP. Microbiological analysis was performed by the checkerboard DNA-DNA hybridization. Results: Changes in bacterial levels from baseline to 15 days after SC were similar in the 2 groups. When subjects were analysed as a single group, significant reductions after SC were observed for Actinomyces gerencseriae, Capnocytophaga ochracea, and Treponema denticola. During the 12-month follow-up, levels of most of the bacteria decreased in both groups in a similar pattern. For instance, Actinomyces israelli, Veillonella parvula, Streptococcus gordonii, C. ochracea, Eikenella corrodens, Eubacterium nodatum, Fusobacterium periodonticum and Fusobacterium nucleatum ssp. polymorphum decreased significantly within the groups. Conclusions: Azithromycin was ineffective in lowering the subgingival levels of important putative periodontal pathogens in young AgP subjects compared to placebo. Clinical significance: Scaling and root planing with adjunctive systemic azithromycin provides little additional benefit compared to placebo in reductions of major subgingival periodontal pathogens.
AB - Objectives: To compare the subgingival microbiological outcomes of azithromycin or placebo as adjuncts to scaling and root planing (SRP) in the treatment of aggressive periodontitis (AgP), and to secondarily evaluate the microbiological effect of supragingival scaling in AgP patients. Methods: Twenty-four AgP subjects 13-26 years of age received a 15-day programme of supragingival scaling (SC) and were then randomly assigned to SRP with systemic azithromycin or placebo. Subgingival samples were taken with sterile paper points at baseline, 15 days after SC, and at 3, 6 and 12 months following SRP. Microbiological analysis was performed by the checkerboard DNA-DNA hybridization. Results: Changes in bacterial levels from baseline to 15 days after SC were similar in the 2 groups. When subjects were analysed as a single group, significant reductions after SC were observed for Actinomyces gerencseriae, Capnocytophaga ochracea, and Treponema denticola. During the 12-month follow-up, levels of most of the bacteria decreased in both groups in a similar pattern. For instance, Actinomyces israelli, Veillonella parvula, Streptococcus gordonii, C. ochracea, Eikenella corrodens, Eubacterium nodatum, Fusobacterium periodonticum and Fusobacterium nucleatum ssp. polymorphum decreased significantly within the groups. Conclusions: Azithromycin was ineffective in lowering the subgingival levels of important putative periodontal pathogens in young AgP subjects compared to placebo. Clinical significance: Scaling and root planing with adjunctive systemic azithromycin provides little additional benefit compared to placebo in reductions of major subgingival periodontal pathogens.
KW - Adolescents/young-adults
KW - Aggressive periodontitis
KW - Azithromycin
KW - Checkerboard DNA-DNA hybridization
KW - Randomized controlled trial
KW - Systemic antibiotics
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U2 - 10.1016/j.jdent.2012.03.004
DO - 10.1016/j.jdent.2012.03.004
M3 - Article
C2 - 22445846
AN - SCOPUS:84861806476
SN - 0300-5712
VL - 40
SP - 556
EP - 563
JO - Journal of Dentistry
JF - Journal of Dentistry
IS - 7
ER -