Adult mesenchymal hamartoma of the liver: Case report and literature review

Zachary Klaassen, Prakash R. Paragi, Ronald S. Chamberlain

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Mesenchymal hamartoma of the liver (MHL) is a rare benign lesion occurring primarily in the pediatric population. While the precise pathogenesis of the tumor is not certain, the most common theory relates to aberrant mesenchyme development in the portal tract likely related to the bile ducts. A 53-year-old female was evaluated for an incidental liver mass. Initial CT scan showed a cystic lesion in the right lobe of the liver and follow-up imaging revealed an increase in size and the percent solid component within the mass. In view of these changes, a nondiagnostic biopsy was obtained followed by extirpation of the lesion. Gross pathological review of the lesion identified a 9 × 9 × 7.5 cm, pink-yellow-tan, gelatinous mass, with a >1 cm clear surgical margin. Histologically, the mass consisted of benign dilated bile ducts, as well as myxoid stroma with spindle cells showing smooth muscle differentiation. The patient was discharged home on postoperative day five. A review of the literature for MHL in adults reports 30 previous cases, predominantly published as individual case reports describing the size, lobe(s) of the liver affected, and the cystic/solid nature of the tumor. MHL in adults may represent a potentially premalignant lesion, as the emerging literature supports a potential relationship between MHL and malignant undifferentiated embryonal sarcoma in regards to cytogenetic analysis. Aggressive surgical management of MHL in adults is mandated when feasible.

Original languageEnglish (US)
Pages (from-to)84-92
Number of pages9
JournalCase Reports in Gastroenterology
Issue number1
StatePublished - 2010
Externally publishedYes


  • Hepatic mass
  • Hepatobiliary surgery
  • Mesenchymal hamartoma
  • Undifferentiated embryonal sarcoma

ASJC Scopus subject areas

  • Gastroenterology


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