TY - JOUR
T1 - Advanced paternal age and parental history of schizophrenia
AU - Miller, Brian J
AU - Suvisaari, Jaana
AU - Miettunen, Jouko
AU - Järvelin, Marjo Riitta
AU - Haukka, Jari
AU - Tanskanen, Antti
AU - Lönnqvist, Jouko
AU - Isohanni, Matti
AU - Kirkpatrick, Brian
N1 - Funding Information:
Dr. Miettunen received grant support from the Academy of Finland (125853) and an Independent Investigator award from NARSAD: The Brain and Behavior Research Fund.
Funding Information:
Dr. Miller received grant support from the University of Oulu, Finland, and Oy H. Lundbeck Ab. Dr. Suvisaari received grant support from the Academy of Finland.
Funding Information:
Dr. Isohanni received grant support from the Sigrid Juselius Foundation and the Academy of Finland (110143 and 212848) and NARSAD.
Funding Information:
Dr. Kirkpatrick received grant support from R01 DK069265 from the National Institute of Diabetes and Digestive and Kidney Diseases.
PY - 2011/12
Y1 - 2011/12
N2 - Introduction: Advanced paternal age (APA) is a risk factor for nonaffective psychosis (NAP) in the offspring, although the mechanism(s) of this association are not clear. The aim of this study was to examine whether later childbearing can be explained by parental schizophrenia, and in doing so, further evaluate the "de novo mutation" hypothesis for the association between APA and NAP. Methods: Using binary logistic regression, the association between APA and parental history of schizophrenia in the offspring, considering maternal and paternal history separately, was examined in 1) all persons with NAP born in Finland between 1950 and 1969 (Finnish NAP Cohort, n = 13,712), and 2) members of the Northern Finland 1966 Birth Cohort (NFBC 1966, n = 10,224), a general population birth cohort. Results: In the Finnish NAP Cohort, having a mother with schizophrenia was associated with APA (Odds Ratio [OR] for linear trend = 1.20, 95% confidence interval 1.12-1.29, p < 0.01). In the NFBC 1966 sample, having a mother with schizophrenia was associated with APA at the trend level (OR = 1.14, 0.99-1.31, p = 0.07). By contrast, there was no association between having a father with schizophrenia and APA. Discussion: In both a general population cohort and a birth cohort of subjects with nonaffective psychosis, APA was associated with maternal, but not paternal, schizophrenia. These findings suggest that increased genetic risk from the mother may explain the association between APA and nonaffective psychosis, and argue against the "de novo mutation" hypothesis.
AB - Introduction: Advanced paternal age (APA) is a risk factor for nonaffective psychosis (NAP) in the offspring, although the mechanism(s) of this association are not clear. The aim of this study was to examine whether later childbearing can be explained by parental schizophrenia, and in doing so, further evaluate the "de novo mutation" hypothesis for the association between APA and NAP. Methods: Using binary logistic regression, the association between APA and parental history of schizophrenia in the offspring, considering maternal and paternal history separately, was examined in 1) all persons with NAP born in Finland between 1950 and 1969 (Finnish NAP Cohort, n = 13,712), and 2) members of the Northern Finland 1966 Birth Cohort (NFBC 1966, n = 10,224), a general population birth cohort. Results: In the Finnish NAP Cohort, having a mother with schizophrenia was associated with APA (Odds Ratio [OR] for linear trend = 1.20, 95% confidence interval 1.12-1.29, p < 0.01). In the NFBC 1966 sample, having a mother with schizophrenia was associated with APA at the trend level (OR = 1.14, 0.99-1.31, p = 0.07). By contrast, there was no association between having a father with schizophrenia and APA. Discussion: In both a general population cohort and a birth cohort of subjects with nonaffective psychosis, APA was associated with maternal, but not paternal, schizophrenia. These findings suggest that increased genetic risk from the mother may explain the association between APA and nonaffective psychosis, and argue against the "de novo mutation" hypothesis.
KW - Epidemiology
KW - Family history
KW - Paternal age
KW - Schizophrenia
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U2 - 10.1016/j.schres.2011.08.013
DO - 10.1016/j.schres.2011.08.013
M3 - Article
C2 - 21937198
AN - SCOPUS:81955167945
SN - 0920-9964
VL - 133
SP - 125
EP - 132
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -