TY - JOUR
T1 - Advances in Molecular biomarker for early diagnosis of Osteoarthritis
AU - Munjal, Akul
AU - Bapat, Santul
AU - Hubbard, Daniel
AU - Hunter, Monte
AU - Kolhe, Ravindra
AU - Fulzele, Sadanand
N1 - Publisher Copyright:
© 2019 Akul Munjal et al., published by De Gruyter.
PY - 2019
Y1 - 2019
N2 - Osteoarthritis (OA) is a chronic degenerative joint disease. The pathogenesis is poorly understood. What is known is that OA is characterized by imbalance in anabolic and catabolic gene expression in articular chondrocytes. This results in bone on bone articulations resulting in impaired mobility and joint pain. Although the cause of OA is unknown, comorbidities include: aging, obesity, and mechanical stress. Currently the only diagnostic modalities are radiology and physical examination, and early detection is rare. Biomarkers are quantifiable substances, and their presence can be suggestive of a certain phenomenon or disease. Biomarkers are popular for early diagnosis for pathological conditions in the fields of oncology, cardiology, and endocrinology. This review has systematically reviewed the literature about biomarkers in the field of OA, specifically protein, miRNA, and metabolic biomarkers found in the blood, urine, and synovial fluid.
AB - Osteoarthritis (OA) is a chronic degenerative joint disease. The pathogenesis is poorly understood. What is known is that OA is characterized by imbalance in anabolic and catabolic gene expression in articular chondrocytes. This results in bone on bone articulations resulting in impaired mobility and joint pain. Although the cause of OA is unknown, comorbidities include: aging, obesity, and mechanical stress. Currently the only diagnostic modalities are radiology and physical examination, and early detection is rare. Biomarkers are quantifiable substances, and their presence can be suggestive of a certain phenomenon or disease. Biomarkers are popular for early diagnosis for pathological conditions in the fields of oncology, cardiology, and endocrinology. This review has systematically reviewed the literature about biomarkers in the field of OA, specifically protein, miRNA, and metabolic biomarkers found in the blood, urine, and synovial fluid.
KW - Biomarker
KW - Diagnosis
KW - Osteoarthritis
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U2 - 10.1515/bmc-2019-0014
DO - 10.1515/bmc-2019-0014
M3 - Article
C2 - 31401621
AN - SCOPUS:85071000112
SN - 1868-5021
VL - 10
SP - 111
EP - 119
JO - Biomolecular Concepts
JF - Biomolecular Concepts
IS - 1
ER -