Advances in transoral fundoplication for oesophageal reflux

Bradley Zagol, Dean Mikami

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Background: The purpose of this review was to evaluate transoral fundoplication devices for gastro-oesophageal reflux disease that have been commercially available within the last 5 years. Methods: Literature databases including Medline and Pubmed were searched from January 2005 to November 2010. Both blinded and unblinded randomized studies were evaluated. Results: We reviewed the literature for evaluations of primary transoral endoluminal fundoplication devices which included EndoCinch, NDO Plicator, Esophyx, and Stretta. Reviews of all studies with greater than 20 patients were evaluated to assess the efficacy and safety of transoral fundoplication devices. These endoluminal devices were primary matched against sham procedures. The EndoCinch and Stretta procedures were the only devices compared to laparoscopic fundoplication, the current standard for surgical management of gastro-oesophageal reflux disease. Conclusion: The field of endoluminal treatment of gastro-oesophageal reflux disease has gained popularity over the last several years. Endoluminal treatment of gastro-oesophageal reflux disease has been shown to be safe and effective in recent studies. We still believe more randomized prospective studies need to be carried out to determine if endoluminal therapies will be a durable option for patients with gastro-oesophageal reflux disease. Continuing research will further the advancement of endoluminal gastro-oesophageal reflux disease procedures in the future.

Original languageEnglish (US)
Pages (from-to)361-364
Number of pages4
JournalDigestive and Liver Disease
Issue number5
StatePublished - May 2011
Externally publishedYes


  • Endoluminal
  • Gastro-oesophageal
  • Reflux
  • Treatment

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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