To the Editor: Blumberg and London clearly summarized the several lines of data that support the hypothesis that primary carcinoma is related to persistent infection with hepatitis B virus (HBV) (March 26 issue).1 However, they do not discuss the very high incidence of aflatoxin contamination of foods, which occurs in many of the same areas of the world where there is a high carriage rate of HBV.2 Aflatoxins (and other mycotoxins) may have a primary or secondary role in the development of primary hepatic carcinoma. They depress cellular immunity and thus may enhance a tendency toward persistent HBV infection, or.
|Original language||English (US)|
|Number of pages||1|
|Journal||New England Journal of Medicine|
|State||Published - Oct 1 1981|
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