TY - JOUR
T1 - African Americans with pancreatic ductal adenocarcinoma exhibit gender differences in Kaiso expression
AU - Jones, Jacqueline
AU - Mukherjee, Angana
AU - Karanam, Balasubramanyam
AU - Davis, Melissa
AU - Jaynes, Jesse
AU - Reams, R. Renee
AU - Dean-Colomb, Windy
AU - Yates, Clayton
N1 - Funding Information:
This work was supported by the Department of Defense Prostate Cancer Research Program ( PC120913 ) [CY], G12 RR03059-21A1 ( NIH/RCMI ) [CY], ( NIH/NCI ) 1 R21 CA188799-01 [CY] and U54 CA118623 (NIH/NCI) [CY], a pilot project on Pancreatic SPORE 2 P50 CA101955-11 [CY]. Statistical analysis was performed by Tuskegee University Statistical Core.
Publisher Copyright:
© 2016 Elsevier Ireland Ltd
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Kaiso, a bi-modal transcription factor, regulates gene expression, and is elevated in breast, prostate, and colon cancers. Depletion of Kaiso in other cancer types leads to a reduction in markers for the epithelial–mesenchymal transition (EMT) (Jones et al., 2014), however its clinical implications in pancreatic ductal adenocarcinoma (PDCA) have not been widely explored. PDCA is rarely detected at an early stage but is characterized by rapid progression and invasiveness. We now report the significance of the subcellular localization of Kaiso in PDCAs from African Americans. Kaiso expression is higher in the cytoplasm of invasive and metastatic pancreatic cancers. In males, cytoplasmic expression of Kaiso correlates with cancer grade and lymph node positivity. In male and female patients, cytoplasmic Kaiso expression correlates with invasiveness. Also, nuclear expression of Kaiso increases with increased invasiveness and lymph node positivity. Further, analysis of the largest PDCA dataset available on ONCOMINE shows that as Kaiso increases, there is an overall increase in Zeb1, which is the inverse for E-cadherin. Hence, these findings suggest a role for Kaiso in the progression of PDCAs, involving the EMT markers, E-cadherin and Zeb1.
AB - Kaiso, a bi-modal transcription factor, regulates gene expression, and is elevated in breast, prostate, and colon cancers. Depletion of Kaiso in other cancer types leads to a reduction in markers for the epithelial–mesenchymal transition (EMT) (Jones et al., 2014), however its clinical implications in pancreatic ductal adenocarcinoma (PDCA) have not been widely explored. PDCA is rarely detected at an early stage but is characterized by rapid progression and invasiveness. We now report the significance of the subcellular localization of Kaiso in PDCAs from African Americans. Kaiso expression is higher in the cytoplasm of invasive and metastatic pancreatic cancers. In males, cytoplasmic expression of Kaiso correlates with cancer grade and lymph node positivity. In male and female patients, cytoplasmic Kaiso expression correlates with invasiveness. Also, nuclear expression of Kaiso increases with increased invasiveness and lymph node positivity. Further, analysis of the largest PDCA dataset available on ONCOMINE shows that as Kaiso increases, there is an overall increase in Zeb1, which is the inverse for E-cadherin. Hence, these findings suggest a role for Kaiso in the progression of PDCAs, involving the EMT markers, E-cadherin and Zeb1.
KW - EMT markers
KW - Kaiso
KW - Pancreatic ductal carcinoma
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U2 - 10.1016/j.canlet.2016.06.025
DO - 10.1016/j.canlet.2016.06.025
M3 - Article
C2 - 27424525
AN - SCOPUS:84981172782
SN - 0304-3835
VL - 380
SP - 513
EP - 522
JO - Cancer Letters
JF - Cancer Letters
IS - 2
ER -