Aging diabetes, deconstructing the cerebrovascular wall

Fan Fan, George W. Booz, Richard J. Roman

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Aging, diabetes (DM), and hypertension are leading causes of cerebrovascular diseases (CVDs), contributing to stroke and cognitive impairments and CVD-related long-term disability and death. Emerging evidence suggests that mural cells on the cerebrovascular wall play an essential role in the regulation of cerebral vascular function. However, underlying mechanisms of how vascular smooth muscle cells (VSMCs) and pericytes interact with other cerebral vascular cells to modulate the autoregulation of cerebral blood flow (CBF) and maintain blood-brain barrier (BBB) integrity in aging and DM are just beginning to be understood.

Original languageEnglish (US)
Pages (from-to)9158-9159
Number of pages2
Issue number7
StatePublished - Apr 15 2021
Externally publishedYes


  • aging
  • cerebral blood flow
  • hyperglycemia
  • pericytes
  • vascular smooth muscle cells

ASJC Scopus subject areas

  • Aging
  • Cell Biology


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