| Original language | English (US) |
|---|---|
| Pages (from-to) | 293-294 |
| Number of pages | 2 |
| Journal | Trends in Immunology |
| Volume | 30 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2009 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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In: Trends in Immunology, Vol. 30, No. 7, 07.2009, p. 293-294.
Research output: Contribution to journal › Editorial › peer-review
}
TY - JOUR
T1 - Aging in the context of immunological architecture, function and disease outcomes
AU - DiCarlo, Andrea L.
AU - Fuldner, Rebecca
AU - Kaminski, Joseph
AU - Hodes, Richard
N1 - Funding Information: The aging immune system demonstrates a reduced capacity to mount a robust immune response (immunosenescence), thereby increasing the susceptibility to various infectious agents, cancers and diseases in elderly individuals. Defects in immune response that develop with advanced age also result in diminished vaccine efficacy, creating a major public health burden. In addition, radiation and chemical exposure and certain disease states can accelerate the progression of immunosenescence. An area of recent clinical focus is the development of vaccine strategies that would be effective across all age groups and would afford some degree of protection to older individuals to emerging or antibiotic-resistant pathogens. Further elucidation of the mechanisms underlying immunosenescence and identification of the most crucial age-related defects in immune response will lead to more effective strategies to boost immune function in the elderly. To discuss these and other research areas, the US–Japan Cooperative Medical Science Program (US Department of State), in conjunction with the National Institute of Allergy and Infectious Diseases, the National Institute of Aging, the Radiation Effects Research Foundation, the Ministry of Foreign Affairs and the Ministry of Education, Culture, Sports, Science and Technology of Japan, hosted a meeting in June 2008 in San Francisco. Topics discussed at the workshop included relative contributions of age-related defects in the function of T cells, B cells and various innate immune cells to the immunosenescent phenotype. Presentations also explored ways to offset the deleterious effects of aging through immune reconstitution and novel vaccination strategies. Although this meeting was limited to US and Asian researchers, articles within this special issue have been written by investigators throughout the world, including Europe, Australia, Asia and North America. Within this single topic issue of Trends in Immunology are 12 papers that represent highlights of many presentations from the June meeting. This special issue also adds to this body of knowledge by exploring topics not fully discussed at the meeting, such as the evolutionary context of aging.
PY - 2009/7
Y1 - 2009/7
UR - http://www.scopus.com/inward/record.url?scp=67649409335&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649409335&partnerID=8YFLogxK
U2 - 10.1016/j.it.2009.05.003
DO - 10.1016/j.it.2009.05.003
M3 - Editorial
C2 - 19541534
AN - SCOPUS:67649409335
SN - 1471-4906
VL - 30
SP - 293
EP - 294
JO - Trends in Immunology
JF - Trends in Immunology
IS - 7
ER -