Abstract
Agrin is utilized by motor neurons to stimulate the LRP4-MuSK receptor in muscles for neuromuscular junction (NMJ) formation. Recent studies of cancer have identified novel functions of the low-density lipoprotein receptor-related protein 4–muscle-specific kinase (LRP4–MuSK) pathway. Agrin may act as a mechanotransduction signal in the extracellular matrix (ECM) to coordinate the cross-talk between the LRP4–MuSK pathway and integrin-focal adhesion pathway. Ensuing Yes-associated protein (YAP) activation promotes hepatocellular carcinoma (HCC). Here, we discuss the implications of the converged pathways in NMJ formation and liver cancer.
Original language | English (US) |
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Pages (from-to) | 247-248 |
Number of pages | 2 |
Journal | Trends in Cancer |
Volume | 3 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2017 |
Keywords
- Agrin
- LRP4
- MuSK
- YAP
- liver cancer
- neuromuscular junction
ASJC Scopus subject areas
- Oncology
- Cancer Research