Aid to accurate clinical staging. Histopathologic grading in prostatic cancer

R. Thomas, R. W. Lewis, D. P. Sarma, G. B. Coker, M. K. Rao, J. A. Roberts

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Recently, pathologic staging systems have been used to aid in accurate clinical assignment of prostatic disease. With this in mind, we reviewed retrospectively 130 patients who were diagnosed as having prostatic cancer either by needle biopsy or by study of transurethral resection chips. These specimens were graded by the Gleason and Roswell Park histopathologic grading systems. Grading was done by 2 pathologists independently and without knowledge of the results of final surgical staging. All patients were without evidence of metastases by standard diagnostic studies, and all underwent pelvic lymphadenectomy and radical prostatectomy if nodes were grossly negative. The surgical specimens were examined and the final clinical stage was correlated with the histopathologic grading. Independently, the Gleason rather than the Roswell Park system was slightly more accurate and was a more reliable predictor of the surgical stage of the disease. Of the patients with a Gleason sum of 7 or above 86% had at least stage C disease, whereas the disease had been staged preoperatively as A or B. All patients with a Gleason sum of 2 to 5 had stage A or B disease.

Original languageEnglish (US)
Pages (from-to)726-728
Number of pages3
JournalUnknown Journal
Issue number4
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Urology


Dive into the research topics of 'Aid to accurate clinical staging. Histopathologic grading in prostatic cancer'. Together they form a unique fingerprint.

Cite this