Albumin levels in pregnancy: a hypothesis-decreased levels of albumin are related to increased levels of alpha-fetoprotein

James E. Maher; Robert L. Goldenberg; Tsunenobu Tamura; Suzanne P. Cliver; Howard J. Hoffman; Richard O. Davis; Larry Boots

doi:10.1016/0378-3782(93)90178-W

Albumin levels in pregnancy: a hypothesis-decreased levels of albumin are related to increased levels of alpha-fetoprotein

James E. Maher, Robert L. Goldenberg, Tsunenobu Tamura, Suzanne P. Cliver, Howard J. Hoffman, Richard O. Davis, Larry Boots

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Serum albumin levels decrease during pregnancy while the concentration of most other maternal serum proteins of hepatic origin remain stable or increase. In a study of 289 women, most maternal characteristics such as race, age, smoking, a history of previous low birth-weight, infant sex and gestational age at delivery were not related to maternal serum albumin levels at 18 or 30 weeks' gestational age. The degree of maternal obesity significantly correlated with the concentration of albumin. There was a significant negative correlation in individual women between maternal serum levels of albumin and a-fetoprotein, with high levels of maternal serum a-fetoprotein predicting lower levels of albumin. We hypothesize that there may be a negative feedback effect of α-fetoprotein of fetal origin on the maternal production of albumin during pregnancy.

Original language	English (US)
Pages (from-to)	209-215
Number of pages	7
Journal	Early Human Development
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/0378-3782(93)90178-W
State	Published - Oct 1993
Externally published	Yes

Keywords

Albumin
Alpha-fetoprotein
Pregnancy

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0378-3782(93)90178-W

Cite this

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title = "Albumin levels in pregnancy: a hypothesis-decreased levels of albumin are related to increased levels of alpha-fetoprotein",

abstract = "Serum albumin levels decrease during pregnancy while the concentration of most other maternal serum proteins of hepatic origin remain stable or increase. In a study of 289 women, most maternal characteristics such as race, age, smoking, a history of previous low birth-weight, infant sex and gestational age at delivery were not related to maternal serum albumin levels at 18 or 30 weeks' gestational age. The degree of maternal obesity significantly correlated with the concentration of albumin. There was a significant negative correlation in individual women between maternal serum levels of albumin and a-fetoprotein, with high levels of maternal serum a-fetoprotein predicting lower levels of albumin. We hypothesize that there may be a negative feedback effect of α-fetoprotein of fetal origin on the maternal production of albumin during pregnancy.",

keywords = "Albumin, Alpha-fetoprotein, Pregnancy",

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year = "1993",

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language = "English (US)",

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T2 - a hypothesis-decreased levels of albumin are related to increased levels of alpha-fetoprotein

AU - Maher, James E.

AU - Goldenberg, Robert L.

AU - Tamura, Tsunenobu

AU - Cliver, Suzanne P.

AU - Hoffman, Howard J.

AU - Davis, Richard O.

AU - Boots, Larry

PY - 1993/10

Y1 - 1993/10

N2 - Serum albumin levels decrease during pregnancy while the concentration of most other maternal serum proteins of hepatic origin remain stable or increase. In a study of 289 women, most maternal characteristics such as race, age, smoking, a history of previous low birth-weight, infant sex and gestational age at delivery were not related to maternal serum albumin levels at 18 or 30 weeks' gestational age. The degree of maternal obesity significantly correlated with the concentration of albumin. There was a significant negative correlation in individual women between maternal serum levels of albumin and a-fetoprotein, with high levels of maternal serum a-fetoprotein predicting lower levels of albumin. We hypothesize that there may be a negative feedback effect of α-fetoprotein of fetal origin on the maternal production of albumin during pregnancy.

AB - Serum albumin levels decrease during pregnancy while the concentration of most other maternal serum proteins of hepatic origin remain stable or increase. In a study of 289 women, most maternal characteristics such as race, age, smoking, a history of previous low birth-weight, infant sex and gestational age at delivery were not related to maternal serum albumin levels at 18 or 30 weeks' gestational age. The degree of maternal obesity significantly correlated with the concentration of albumin. There was a significant negative correlation in individual women between maternal serum levels of albumin and a-fetoprotein, with high levels of maternal serum a-fetoprotein predicting lower levels of albumin. We hypothesize that there may be a negative feedback effect of α-fetoprotein of fetal origin on the maternal production of albumin during pregnancy.

KW - Albumin

KW - Alpha-fetoprotein

KW - Pregnancy

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Albumin levels in pregnancy: a hypothesis-decreased levels of albumin are related to increased levels of alpha-fetoprotein

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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