TY - JOUR
T1 - Aldosterone contributes to elevated left ventricular mass in black boys
AU - Murro, Diana G.
AU - Beavers, Melinda
AU - Harshfield, Gregory A.
AU - Kapuku, Gaston K.
N1 - Funding Information:
This study was supported by the grants HL064225 HL 059954, and HL 0699999 of the National Institutes of Health. There was no industry support for this study
PY - 2013/4
Y1 - 2013/4
N2 - Background: Left ventricular hypertrophy (LVH) poses a great risk of cardiovascular morbidity and mortality in adults and may pose a serious risk in children. Adult studies have shown that renin-angiotensin-aldosterone system (RAAS) levels directly correlate with left ventricular mass index (LVMI). The purpose of this study is to explore race- and sex-related effects of the RAAS on LVMI in adolescents. Methods: Data were collected from a sample of 89 blacks (44 girls, 45 boys) and 102 whites (40 girls, 62 boys) aged 15-19. Data collected included sex, age, body mass index (BMI), LVMI, baseline blood pressure, and levels of aldosterone and angiotensin II. Results: In black males, increased aldosterone levels correlated with decreased sodium excretion (r = -0.336, p = 0.024), increased blood pressure (r = 0.358, p = 0.016), and increased LVMI (r = 0.342, p = 0.022). In black females, increased aldosterone levels correlated with increased baseline blood pressure (r = 0.356, p = 0.018). In white males, increased aldosterone correlated with decreased sodium excretion (r = -0.391, p = 0.002). In white females, aldosterone levels correlated with increased baseline blood pressure (r = 0.323, p = 0.042) and decreased sodium excretion (r = -0.342, p = 0.031). Conclusions: The results suggest the following model in black males: increased aldosterone leads to increased sodium retention, causing a volume-mediated increase in blood pressure; increased blood pressure results in increased left ventricular mass, and eventually LVH.
AB - Background: Left ventricular hypertrophy (LVH) poses a great risk of cardiovascular morbidity and mortality in adults and may pose a serious risk in children. Adult studies have shown that renin-angiotensin-aldosterone system (RAAS) levels directly correlate with left ventricular mass index (LVMI). The purpose of this study is to explore race- and sex-related effects of the RAAS on LVMI in adolescents. Methods: Data were collected from a sample of 89 blacks (44 girls, 45 boys) and 102 whites (40 girls, 62 boys) aged 15-19. Data collected included sex, age, body mass index (BMI), LVMI, baseline blood pressure, and levels of aldosterone and angiotensin II. Results: In black males, increased aldosterone levels correlated with decreased sodium excretion (r = -0.336, p = 0.024), increased blood pressure (r = 0.358, p = 0.016), and increased LVMI (r = 0.342, p = 0.022). In black females, increased aldosterone levels correlated with increased baseline blood pressure (r = 0.356, p = 0.018). In white males, increased aldosterone correlated with decreased sodium excretion (r = -0.391, p = 0.002). In white females, aldosterone levels correlated with increased baseline blood pressure (r = 0.323, p = 0.042) and decreased sodium excretion (r = -0.342, p = 0.031). Conclusions: The results suggest the following model in black males: increased aldosterone leads to increased sodium retention, causing a volume-mediated increase in blood pressure; increased blood pressure results in increased left ventricular mass, and eventually LVH.
KW - Adolescents
KW - Aldosterone
KW - Angiotensin
KW - Hypertension
KW - Left ventricular hypertrophy
KW - Renin
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U2 - 10.1007/s00467-012-2367-6
DO - 10.1007/s00467-012-2367-6
M3 - Article
C2 - 23179199
AN - SCOPUS:84879957997
SN - 0931-041X
VL - 28
SP - 655
EP - 660
JO - Pediatric Nephrology
JF - Pediatric Nephrology
IS - 4
ER -